HERG, A HUMAN INWARD RECTIFIER IN THE VOLTAGE-GATED POTASSIUM CHANNEL FAMILY
HERG, A HUMAN INWARD RECTIFIER IN THE VOLTAGE-GATED POTASSIUM CHANNEL FAMILY
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DOI：
10.1126/science.7604285
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发表时间：
1995-07-07
期刊：
影响因子：
56.9
通讯作者：
ROBERTSON, GA
中科院分区：
文献类型：
--
作者：
TRUDEAU, MC;WARMKE, JW;ROBERTSON, GA
与EAG家族中电压门控的外向整流钾通道的其他成员不同，人类EAG相关基因(HERG)现在被证明编码一种内向整流钾通道。HERG通道的特性与EAG相关和其他外向整流型含S4的钾通道的门控特性一致，但增加了一种在去极化过程中减弱钾外流的失活机制。由于HERG基因突变导致一种形式的长QT综合征，HERG通道功能的这些特性可能对维持正常的心律失常至关重要。
In contrast to other members of the Eag family of voltage-gated, outwardly rectifying potassium channels, the human eag-related gene (HERG) has now been shown to encode an inwardly rectifying potassium channel. The properties of HERG channels are consistent with the gating properties of Eag-related and other outwardly rectifying, S4-containing potassium channels, but with the addition of an inactivation mechanism that attenuates potassium efflux during depolarization. Because mutations in HERG cause a form of long-QT syndrome, these properties of HERG channel function may be critical to the maintenance of normal cardiac rhythmicity.