Neuroprotective effects of 2,5-diaryl-3,4-dimethyltetrahydrofuran neolignans
Neuroprotective effects of 2,5-diaryl-3,4-dimethyltetrahydrofuran neolignans
复制标题
DOI：
10.1248/bpb.28.289
复制
发表时间：
2005-02-01
影响因子：
2
通讯作者：
Fukuyama, Y
中科院分区：
文献类型：
--
作者：
Zhai, HF;Inoue, T;Fukuyama, Y
我们以前报道过马兜铃中的talaumidin（1）的神经营养作用。在本研究中，我们在原代培养的大鼠神经元中比较了从同一种植物中分离的其他六种2，5-二芳基-3，4-二甲基-四氢呋喃新木脂素，即藜芦素（2）、galgravin（3）、马兜铃木质素（4）、nectandrin A（5）、异野桐素B（6）和nectandrin B（7）与化合物I的神经营养和神经保护作用。化合物3-7促进神经元存活和突起生长，其中化合物6和7显示出与化合物1相当的神经营养活性。此外，在培养的大鼠海马神经元中，化合物1-7保护海马神经元免于淀粉样蛋白β肽（Abeta（25-35））诱导的细胞毒性，而化合物1和4-7保护免于1-甲基-4-苯基吡啶鎓离子（MPP+）诱导的毒性引起的神经元死亡。
We previously reported the neurotrophic effects of talaumidin (1) from Aristolochia arcuata MASTERS. In the present study, we compared the neurotrophic and neuroprotective effects of six other 2,5-diaryl-3,4-dimethyl-tetrahydrofuran neolignans isolated from the same plant, veraguensin (2), galgravin (3), aristolignin (4), nectandrin A (5), isonectandrin B (6), and nectandrin B (7), with compound I in primary cultured rat neurons. Compounds 3-7 promoted neuronal survival and neurite outgrowth, among which compounds 6 and 7 showed neurotrophic activity comparable with that of 1. Furthermore, compounds 1-7 protected hippocampal neurons against amyloid beta peptide (Abeta(25-35))-induced cytotoxicity, while compounds 1 and 4-7 protected against neuronal death from 1-methyl-4-phenylpyridinium ion (MPP+)-induced toxicity in cultured rat hippocampal neurons.