Characterization and quantification of vortex flow in the human left ventricle by contrast echocardiography using vector particle image velocimetry.
Characterization and quantification of vortex flow in the human left ventricle by contrast echocardiography using vector particle image velocimetry.
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DOI：
10.1016/j.jcmg.2008.06.008
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发表时间：
2008-11
期刊：
影响因子：
--
通讯作者：
Vannan MA
中科院分区：
文献类型：
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作者：
Hong GR;Pedrizzetti G;Tonti G;Li P;Wei Z;Kim JK;Baweja A;Liu S;Chung N;Houle H;Narula J;Vannan MA
本研究的目的是：1)评价超声心动图(CE)评价左心室(LV)涡流分析的可行性；2)对正常人和左心室收缩功能不全患者的LV涡流进行定性和定量。在LV充盈过程中形成的旋涡具有特定的几何形状和解剖位置，这是射血过程中定向血流的关键决定因素。因此，评估涡流模式以更好地了解左心室功能具有重要的临床意义。25例患者(10例正常和15例左心室收缩功能异常患者)接受了静脉造影剂Definity(Bristol-Myers Squibb医学成像公司，北比勒里卡，马萨诸塞州)的CE检查。用粒子图像测速仪测量了流场的速度矢量和涡量。测量了旋涡深度、横向位置、长度、宽度和球度指数等平均旋涡参数。还估算了涡动参数，包括相对强度、涡旋相对强度和涡旋脉动相关性。左心室功能异常组的涡流深度和涡流长度明显低于对照组(分别为0.443±0.04vs 0.482±0.06p<；0.05；0.366±0.06vs 0.467±0.05，p<；0.01)。左心室功能异常组的涡旋宽度较大(0.209±0.05vs.0.128±0.06，p<；0.001)，球形指数较低(1.86±0.5vs.3.66±0.6，p<；0.001)。左心功能异常组的相对强度(1.13±0.4vs.2.10±0.8，p<；0.001)、涡旋相对强度(0.57±0.2vs.1.19±0.5，p<；0.001)、涡动相关系数(0.63±0.2vs.1.31±0.5，p<；0.001)显著降低。应用粒子图像测速仪对正常人和左心室收缩功能不全患者进行超声心动图定量测量左心室涡度排列是可行的，其涡度成像可作为评价血流结构的主要量值。
The aims of this study were to: 1) assess the feasibility of left ventricular (LV) vortex flow analysis using contrast echocardiography (CE); and 2) characterize and quantify LV vortex flow in normal subjects and patients with LV systolic dysfunction. Vortices that form during LV filling have specific geometry and anatomical locations that are critical determinants of directed blood flow during ejection. Therefore, it is clinically relevant to assess the vortex flow patterns to better understand the LV function. Twenty-five patients (10 normal and 15 patients with abnormal LV systolic function) underwent CE with intravenous contrast agent, Definity (Bristol-Myers Squibb Medical Imaging, Inc., North Billerica, Massachusetts). The velocity vector and vorticity were estimated by particle image velocimetry. Average vortex parameters including vortex depth, transverse position, length, width, and sphericity index were measured. Vortex pulsatility parameters including relative strength, vortex relative strength, and vortex pulsation correlation were also estimated. Vortex depth and vortex length were significantly lower in the abnormal LV function group (0.443 ± 0.04 vs. 0.482 ± 0.06, p < 0.05; 0.366 ± 0.06 vs. 0.467 ± 0.05, p < 0.01, respectively). Vortex width was greater (0.209 ± 0.05 vs. 0.128 ± 0.06, p < 0.01) and sphericity index was lower (1.86 ± 0.5 vs. 3.66 ± 0.6, p < 0.001) in the abnormal LV function group. Relative strength (1.13 ± 0.4 vs. 2.10 ± 0.8, p < 0.001), vortex relative strength (0.57 ± 0.2 vs. 1.19 ± 0.5, p < 0.001), and vortex pulsation correlation (0.63 ± 0.2 vs. 1.31 ± 0.5, p < 0.001) were significantly lower in the abnormal LV function group. It was feasible to quantify LV vorticity arrangement by CE using particle image velocimetry in normal subjects and those with LV systolic dysfunction, and the vorticity imaging by CE may serve as a novel approach to depict vortex, the principal quantity to assess the flow structure.