Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress
Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress
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DOI：
10.1080/10286020.2023.2269370
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发表时间：
2023-10-27
影响因子：
1.7
通讯作者：
Ding，Xiao
中科院分区：
文献类型：
--
作者：
Wang，Yin-Yuan;Ni，Jian-Cheng;Ding，Xiao
巴戟天是一种传统的补益中药，已被用于多种疾病的治疗。在此分离得到三个环烯醚萜苷。对药用成分在自噬-溶酶体途径中的作用进行了评估。3种环烯醚萜苷均可诱导TFEB/TFE3介导的溶酶体生物发生并触发自噬。有趣的是，它们促进了TFEB/TFE3的核进口，而不影响它们的核出口，这表明它们在维持溶酶体的动态平衡中发挥了作用。这项研究的结果为自噬激活剂Fromm的鉴定提供了线索。药用价值，并为开发它们治疗氧化应激相关疾病提供了基础。
Morinda officinalisis a traditional Chinese tonic herb, and have been used in the treatment of multiple diseases. Here, three iridoid glycosides isolated fromM. officinaliswere evaluated for their roles in the autophagy-lysosomal pathway. All three iridoid glycosides could induce TFEB/TFE3-mediated lysosomal biogenesis and trigger autophagy. Interestingly, they promoted the nuclear import of TFEB/TFE3 without affecting their nuclear export, suggesting their role in the maintenance of lysosomal homeostasis. The results from this study shed light on the identification of autophagy activators fromM. officinalisand provide a basis for developing them in the treatment of oxidative stress-involved diseases.