Preparation and optimization of calcium fluoride particles for dental applications
Preparation and optimization of calcium fluoride particles for dental applications
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DOI：
10.1007/s10856-014-5200-x
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发表时间：
2014-07-01
影响因子：
3.7
通讯作者：
Lussi, Adrian
中科院分区：
文献类型：
--
作者：
Koeser, Joachim;Carvalho, Thiago Saads;Lussi, Adrian
氟化物因其对牙釉质脱矿/再矿化周期的有益作用而用于牙科护理。为了实现口腔中所需的可溶性氟化物的持续供应，人们采用了不同的方法。在这里，我们介绍了 CaF2 颗粒的制备结果及其作为牙釉质相关氟化物释放库的潜在应用的表征。 CaF2 颗粒通过从规定浓度的可溶性 NaF 和 CaCl2 盐溶液中沉淀来合成，并通过扫描电子显微镜分析其形态。通过调节前体盐溶液的浓度可以合成具有确定尺寸和形状的CaF2颗粒。当以与典型牙科护理产品相关的氟化物浓度施用时，此类颗粒与牙釉质表面相互作用。据观察，合成的 CaF2 颗粒中氟化物的释放很大程度上受溶液中磷酸盐浓度的影响。与不含磷酸盐的缓冲溶液相比，磷酸盐浓度与唾液 (3.5 mM) 相似的生理溶液可将纯 CaF2 颗粒中氟化物的释放量减少 10-20 倍。人类唾液中氟化物的释放量甚至更低。在 CaF2 颗粒合成过程中添加亚化学计量的磷酸盐可以增加氟化物的释放。结果表明，CaF2 颗粒的形态和氟化物释放特性可以调节，并为合成 CaF2 颗粒作为釉质相关氟化物储库的适用性提供了证据。
Fluorides are used in dental care due to their beneficial effect in tooth enamel de-/remineralization cycles. To achieve a desired constant supply of soluble fluorides in the oral cavity, different approaches have been followed. Here we present results on the preparation of CaF2 particles and their characterization with respect to a potential application as enamel associated fluoride releasing reservoirs. CaF2 particles were synthesized by precipitation from soluble NaF and CaCl2 salt solutions of defined concentrations and their morphology analyzed by scanning electron microscopy. CaF2 particles with defined sizes and shapes could be synthesized by adjusting the concentrations of the precursor salt solutions. Such particles interacted with enamel surfaces when applied at fluoride concentrations correlating to typical dental care products. Fluoride release from the synthesized CaF2 particles was observed to be largely influenced by the concentration of phosphate in the solution. Physiological solutions with phosphate concentration similar to saliva (3.5 mM) reduced the fluoride release from pure CaF2 particles by a factor of 10-20 x as compared to phosphate free buffer solutions. Fluoride release was even lower in human saliva. The fluoride release could be increased by the addition of phosphate in substoichiometric amounts during CaF2 particle synthesis. The presented results demonstrate that the morphology and fluoride release characteristics of CaF2 particles can be tuned and provide evidence of the suitability of synthetic CaF2 particles as enamel associated fluoride reservoirs.