Low-dose fourth ventricular bombesin selectively suppresses food intake.
Low-dose fourth ventricular bombesin selectively suppresses food intake.
复制标题
低剂量的第四心室铃蟾肽选择性抑制食物摄入。
DOI：
10.1152/ajpregu.1988.255.6.r988
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Ritter,RC
中科院分区：
文献类型：
--
作者：
Ladenheim,EE;Ritter,RC
蛙皮素（BBS）给药到侧脑室抑制食物摄入。然而，食物摄入的抑制伴随着竞争行为的觉醒，如梳理和增加运动，这是正常饱腹感的非典型表现。我们已经发现，BBS注入大鼠的第四脑室减少食物摄入量的十分之一至百分之一的剂量所需的通过侧脑室。此外，显著减少食物摄入的最低第四脑室剂量并未增加自发活动。这些数据表明，后脑可能是一个更敏感的网站BBS诱导的抑制喂养比前脑网站和BBS的喂养和运动的影响可能涉及可分离的神经基板。
Bombesin (BBS) administered into the lateral cerebral ventricles suppresses food intake. Suppression of food intake, however, is accompanied by arousal of competing behaviors such as grooming and increased locomotion, which are atypical of normal satiety. We have found that BBS infused into the fourth cerebral ventricle in rats reduces food intake at doses one-tenth to one-hundredth of those required via the lateral ventricle. In addition, the lowest fourth ventricular dose that significantly reduced food intake did not increase locomotor activity. These data suggest that the hindbrain may be a more sensitive site for BBS-induced suppression of feeding than forebrain sites and that feeding and locomotor effects of BBS may involve dissociable neural substrates.