Modified Glasgow prognostic score in patients with incurable stage IV colorectal cancer
Modified Glasgow prognostic score in patients with incurable stage IV colorectal cancer
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DOI：
10.1016/j.amjsurg.2012.07.051
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发表时间：
2013-08-01
影响因子：
3
通讯作者：
Sugiyama, Masanori
中科院分区：
文献类型：
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作者：
Kishiki, Tomokazu;Masaki, Tadahiko;Sugiyama, Masanori
背景：改良的格拉斯哥预后评分是一种基于炎症的预后评分。本研究探讨是否这个分数，手术前测量，可以预测术后癌症特异性survival.METHODS：我们回顾性研究了79例结直肠癌患者谁接受了手术治疗的不可治愈的IV期疾病。改良的格拉斯哥预后评分（0 ~ 2）包括C-反应蛋白（10 mg/L）和白蛋白（= 35 g/L）测量值。结果：在总生存期方面，单因素分析显示肺转移、腹膜播散、远处转移、血红蛋白、C-反应蛋白、白蛋白、肿瘤切除、辅助化疗和改良的格拉斯哥预后评分之间存在显著差异。多变量分析显示，血红蛋白（P = .019），辅助化疗（P = 0.002）和改良格拉斯哥预后评分（0和1，低; 2，高）（P = .0001）是术后死亡率的重要预测因素。改良的格拉斯哥预后评分易于获得，可用于预测接受化疗的不可治愈的IV期结直肠癌患者的生存率。手术(c)2013年由Elsevier Inc.出版
BACKGROUND: The modified Glasgow prognostic score is an inflammation-based prognostic score. This study examined whether this score, measured before surgical procedures, could predict postoperative cancer-specific survival.METHODS: We retrospectively studied 79 colorectal cancer patients who underwent a surgical procedure for incurable stage IV disease. The modified Glasgow prognostic score (0 to 2) comprises C-reactive protein (10 mg/L) and albumin (= 35 g/L) measurements.RESULTS: In terms of overall survival, univariate analysis revealed significant differences in the status of lung metastasis, peritoneal dissemination, distant metastasis, hemoglobin, C-reactive protein, albumin, tumor resection, adjuvant chemotherapy, and modified Glasgow prognostic score. Multivariate analysis revealed that hemoglobin (P = .019), adjuvant chemotherapy (P = .002), and modified Glasgow prognostic score (0 and 1, low; 2, high) (P = .0001) were significant predictive factors for postoperative mortality.CONCLUSIONS: The modified Glasgow prognostic score is simple to obtain and useful in predicting survival in incurable stage IV colorectal cancer patients undergoing surgery. (c) 2013 Published by Elsevier Inc.