Positive Effect of Abdominal Breathing Exercise on Gastroesophageal Reflux Disease: A Randomized, Controlled Study
Positive Effect of Abdominal Breathing Exercise on Gastroesophageal Reflux Disease: A Randomized, Controlled Study
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DOI：
10.1038/ajg.2011.420
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发表时间：
2012-03-01
影响因子：
9.8
通讯作者：
Hoffmann, Karl Martin
中科院分区：
文献类型：
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作者：
Eherer, A. J.;Netolitzky, F.;Hoffmann, Karl Martin
预防：食管下括约肌（LES），由括约肌包围，防止胃食管反流。当这些结构变得功能不全时，胃内容物可能导致胃食管反流病（GERD）。对于治疗，总是建议生活方式干预。我们假设，通过积极训练的腿的隔膜作为LES使用呼吸训练练习的一部分，GERD可以积极influenced.METHODS：进行了一项前瞻性随机对照研究。纳入了非糜烂性GERD或食管炎愈合且无大疝和/或既往手术史的患者。患者被随机分配到主动呼吸训练计划组或对照组。在基线和训练4周后评估生活质量（QoL）、pH测定和按需质子泵抑制剂（PPI）使用情况。对于长期随访，邀请所有患者继续进行主动呼吸训练，并在9个月后进一步评估QoL和PPI使用情况。结果：19例非糜烂性GERD或食管炎治愈患者随机分为两组，训练组10例，对照组9例。两组之间的基线患者特征没有差异，所有患者都完成了研究。pH值降低的时间显著减少，
OBJECTIVES: The lower esophageal sphincter (LES), surrounded by diaphragmatic muscle, prevents gastroesophageal reflux. When these structures become incompetent, gastric contents may cause gastroesophageal reflux disease (GERD). For treatment, lifestyle interventions are always recommended. We hypothesized that by actively training the crura of the diaphragm as part of the LES using breathing training exercises, GERD can be positively influenced.METHODS: A prospective randomized controlled study was performed. Patients with non-erosive GERD or healed esophagitis without large hernia and/or previous surgery were included. Patients were randomized and allocated either to active breathing training program or to a control group. Quality of life (QoL), pH-metry, and on-demand proton pump inhibitor (PPI) usage were assessed at baseline and after 4 weeks of training. For long-term follow-up, all patients were invited to continue active breathing training and were further assessed regarding QoL and PPI usage after 9 months. Paired and unpaired t-test was used for statistical analysis.RESULTS: Nineteen patients with non-erosive GERD or healed esophagitis were randomized into two groups (10 training group and 9 control group). There was no difference in baseline patient characteristics between the groups and all patients finished the study. There was a significant decrease in time with a pH