2009 ISSLS Prize Winner: What Influence Does Sustained Mechanical Load Have on Diffusion in the Human Intervertebral Disc? An In Vivo Study Using Serial Postcontrast Magnetic Resonance Imaging
2009 ISSLS Prize Winner: What Influence Does Sustained Mechanical Load Have on Diffusion in the Human Intervertebral Disc? An In Vivo Study Using Serial Postcontrast Magnetic Resonance Imaging
复制标题
DOI：
10.1097/brs.0b013e3181b4df92
复制
发表时间：
2009-10-01
期刊：
影响因子：
3
通讯作者：
Gowland, Penny
中科院分区：
文献类型：
--
作者：
Arun, Ranganathan;Freeman, Brian J. C.;Gowland, Penny
研究设计。利用连续磁共振成像（MRI）研究机械载荷对小溶质进入正常人腰椎间盘（IVD）的影响。探讨持续机械负荷对小溶质在正常腔内和腔外扩散的影响。背景资料摘要。弥散是椎间盘营养的重要来源，负荷对弥散在体内的影响尚不清楚。对8名健康志愿者的40个正常腰椎间盘（MRI）进行连续对比（Gadoteridol） 3特斯拉MRI，分为2期。在第一阶段（对照），志愿者在对比前和注射对比剂后1.5、3、4.5、6和7.5小时的不同时间点进行扫描。在第2阶段，1个月后，同样的志愿者接受持续仰卧负荷4.5小时。分别在1.5、3和4.5小时进行对比前（preload）和对比后（postloading） MRI扫描。然后卸下他们的脊柱，在对比后6和7.5小时进行恢复扫描。使用内部软件对图像进行分析。与未加载椎间盘（UD）相比，加载椎间盘（LD）中心区域不同时间点的重复测量方差分析和两两比较显示，信号强度比（P-1.5h:P-3h:P-4.5h）显著降低
Study Design. An in vivo study of the effects of mechanical loading on transport of small solutes into normal human lumbar intervertebral discs (IVD) using serial post-contrast magnetic resonance imaging (MRI).Objective. To investigate the influence of a sustained mechanical load on diffusion of small solutes in and out of the normal IVD.Summary of Background Data. Diffusion is an important source of disc nutrition and the in vivo effects of load on diffusion in human IVD remains unknown.Methods. Forty normal lumbar discs (on MRI) in 8 healthy volunteers were subjected to serial post contrast (Gadoteridol) 3 Tesla MRI in 2 phases. In phase 1 (control), volunteers were scanned at different time points precontrast and 1.5, 3, 4.5, 6, and 7.5 hours postcontrast injection. In phase 2, 1 month later, the same volunteers were subjected to sustained supine loading for 4.5 hours. MRI scans were performed precontrast (preload) and postcontrast (postloading) at 1.5, 3, and 4.5 hours. Their spines were then unloaded and recovery scans performed at 6 and 7.5 hours postcontrast. In house software was used to analyze images.Results. Repeated-measures ANOVA and pairwise comparisons at different time points in the central region of the loaded disc (LD) compared to the unloaded discs (UD) revealed significantly lower signal intensity ratios (P-1.5h:P-3h:P-4.5h