Computer-aided design of microvasculature systems for use in vascular scaffold production
Computer-aided design of microvasculature systems for use in vascular scaffold production
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DOI：
10.1088/1758-5082/1/3/035002
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发表时间：
2009-09-01
期刊：
影响因子：
9
通讯作者：
Piegl, Les A.
中科院分区：
文献类型：
--
作者：
Mondy, William Lafayette;Cameron, Don;Piegl, Les A.
完整的，功能性的血管网络，其中包括毛细血管结构，在体外生物医学工程是一个先决条件，充分的血管支架生产。毛细血管结构是必要的，因为它们为3D组织结构的生长、功能和维持提供了元素和化合物。立体光刻（STL）微型计算机断层扫描（micro-CT）3D模型的计算机辅助建模是一种技术，使我们能够模拟组织中发现的含有毛细血管床的血管树系统的设计。在我们的第一篇论文中（Mondy等人，2009 Tissue Eng. at press），使用微CT，我们研究了使用血管组织产生能够帮助血管树支架设计的数据的可能性，这将有助于包括毛细血管床结构的完整血管树系统的逆向工程。在本文中，我们使用STL模型的大型数据集的计算机辅助设计（CAD）数据的血管结构，其中包含毛细血管结构，模仿那些在真皮层的兔子皮肤。使用CAD软件，我们从3D STL模型创建了一个生物CAD设计，用于开发含有毛细血管的皮肤血管树支架。该方法被设计为增强各种治疗方案，包括但不限于器官和组织修复、全身性疾病介导和细胞/组织移植治疗。我们成功的体外血管生成方法将允许各种其他类型的3D组织结构的生物工程，并因此大大扩展了生物医学工程技术在生物医学研究和医学领域的潜在应用。
In vitro biomedical engineering of intact, functional vascular networks, which include capillary structures, is a prerequisite for adequate vascular scaffold production. Capillary structures are necessary since they provide the elements and compounds for the growth, function and maintenance of 3D tissue structures. Computer-aided modeling of stereolithographic (STL) micro-computer tomographic (micro-CT) 3D models is a technique that enables us to mimic the design of vascular tree systems containing capillary beds, found in tissues. In our first paper (Mondy et al 2009 Tissue Eng. at press), using micro-CT, we studied the possibility of using vascular tissues to produce data capable of aiding the design of vascular tree scaffolding, which would help in the reverse engineering of a complete vascular tree system including capillary bed structures. In this paper, we used STL models of large datasets of computer-aided design (CAD) data of vascular structures which contained capillary structures that mimic those in the dermal layers of rabbit skin. Using CAD software we created from 3D STL models a bio-CAD design for the development of capillary-containing vascular tree scaffolding for skin. This method is designed to enhance a variety of therapeutic protocols including, but not limited to, organ and tissue repair, systemic disease mediation and cell/tissue transplantation therapy. Our successful approach to in vitro vasculogenesis will allow the bioengineering of various other types of 3D tissue structures, and as such greatly expands the potential applications of biomedical engineering technology into the fields of biomedical research and medicine.