Zika Virus: Medical Countermeasure Development Challenges.
Zika Virus: Medical Countermeasure Development Challenges.
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DOI：
10.1371/journal.pntd.0004530
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发表时间：
2016-03
影响因子：
3.8
通讯作者：
Zika Response Working Group
中科院分区：
文献类型：
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作者：
Malone RW;Homan J;Callahan MV;Glasspool-Malone J;Damodaran L;Schneider Ade B;Zimler R;Talton J;Cobb RR;Ruzic I;Smith-Gagen J;Janies D;Wilson J;Zika Response Working Group
关于在法属波利尼西亚和巴西与寨卡病毒感染相关的原发性小头畸形和格林-巴罗综合征高发率的报告令人担心，在这些地区传播的病毒是一种迅速发展的神经病变性、致畸性和新出现的传染性公共卫生威胁。目前还没有获得许可的针对寨卡病毒感染和疾病的医疗对策（疫苗、疗法或预防性药物）。泛美卫生组织（PAHO）预测，寨卡病毒将继续传播，并最终到达美洲所有有地方性伊蚊的国家和地区。本文综述了寨卡病毒疫情的现状，包括医疗对策方案，重点介绍了流行病学、昆虫媒介、神经病理学、病毒学和免疫学如何为制定和部署医疗对策提供可用的选择和策略。采用了多种信息来源来支持评价。这些包括可公开获得的文献、专利、官方通讯、英语和葡萄牙语非专业出版物。我们向美国、墨西哥和阿根廷的医生分发了在线调查问卷，并对调查结果进行了分析。计算表位分析以及传染病暴发建模和预测实现。汇编了在巴西的实地观察结果，并与公共卫生官员进行了访谈。
Reports of high rates of primary microcephaly and Guillain–Barré syndrome associated with Zika virus infection in French Polynesia and Brazil have raised concerns that the virus circulating in these regions is a rapidly developing neuropathic, teratogenic, emerging infectious public health threat. There are no licensed medical countermeasures (vaccines, therapies or preventive drugs) available for Zika virus infection and disease. The Pan American Health Organization (PAHO) predicts that Zika virus will continue to spread and eventually reach all countries and territories in the Americas with endemic Aedes mosquitoes. This paper reviews the status of the Zika virus outbreak, including medical countermeasure options, with a focus on how the epidemiology, insect vectors, neuropathology, virology and immunology inform options and strategies available for medical countermeasure development and deployment. Multiple information sources were employed to support the review. These included publically available literature, patents, official communications, English and Lusophone lay press. Online surveys were distributed to physicians in the US, Mexico and Argentina and responses analyzed. Computational epitope analysis as well as infectious disease outbreak modeling and forecasting were implemented. Field observations in Brazil were compiled and interviews conducted with public health officials.