Updated Chronic Copper Bioavailability Models for Invertebrates and Algae.
Updated Chronic Copper Bioavailability Models for Invertebrates and Algae.
复制标题
更新了无脊椎动物和藻类的慢性铜生物利用度模型。
DOI：
10.1002/etc.5796
复制
发表时间：
2024
影响因子：
4.1
通讯作者：
Nys C
中科院分区：
文献类型：
--
作者：
Nys C
慢性铜（Cu）的生物利用度模型已成功地实施在欧洲的风险评估框架和合规性评价。然而，它们是近二十年前开发的，需要更新。在这项研究中，我们提出了更新的慢性铜生物利用度模型的无脊椎动物和藻类。他们考虑了最近的生态毒性数据集，并使用了最近的物种形成模型温德米尔腐殖水模型（WHAM）VII和优化的模型结构（即，广义生物利用度模型[gBAM]）。与经典的生物配体模型相反，gBAM通过pH斜率SpH参数化的对数线性关系来模拟pH对Cu 2+毒性的影响。重新校准的无脊椎动物（大型蚤，两个克隆）的SpH参数为−0.208，藻类（近头状针水蚤和普通小球藻）为−0.975。更新后的模型预测了8个不同物种的80%至100%的观察到的效应水平，因子为2。唯一的例外是考虑Hyalella azteca亚慢性7天死亡率的两个数据集之一：pH ≥ 8.3时更新的无脊椎动物模型的预测性能较差，因为pH对Cu 2+毒性的影响似乎取决于pH本身（与pH ≥ 8.1时更新的无脊椎动物模型相比，pH斜率更陡）。更新后的Cu生物利用度模型的预测性能类似于或优于迄今为止在欧洲用于监管应用的模型，但有一个例外（即，H. Azteca）。连同最近发表的鱼类生物利用度模型，在本研究中开发的模型构成了一个完整的，更新的，一致的生物利用度模型集。总体而言，更新后的慢性铜生物利用度模型集是稳健的，可用于监管应用。更新的生物利用度模型集目前在欧盟化学品注册、评估、授权和限制框架法规下使用，以指导Cu.Environ Toxicol Chem 2024;43：450-467的安全使用。© 2023作者。环境毒理学和化学由Wiley Periodicals LLC代表SETAC出版。
Chronic copper (Cu) bioavailability models have been successfully implemented in European risk assessment frameworks and compliance evaluations. However, they were developed almost two decades ago, which calls for an update. In the study, we present updated chronic Cu bioavailability models for invertebrates and algae. They consider recent ecotoxicity data sets and use the more recent speciation model Windermere Humic Aqueous Model (WHAM) VII and an optimized model structure (i.e., a generalized bioavailability model [gBAM]). Contrary to the classic biotic ligand model, a gBAM models the effect of pH on Cu2+toxicity via a log‐linear relationship parametrized through the pH slopeSpH. The recalibratedSpHparameters are −0.208 for invertebrates (Daphnia magna, two clones) and −0.975 for algae (Raphidocelis subcapitataandChlorella vulgaris). The updated models predict 80% to 100% of the observed effect levels for eight different species within a factor of 2. The only exception was one of the two data sets considering subchronic 7‐day mortality toHyalella azteca: the prediction performance of the updated invertebrate model at pH ≥ 8.3 was poor because the effect of pH on Cu2+toxicity appeared to be dependent on the pH itself (with a steeper pH slope compared with the updated invertebrate model at pH ≥ 8.1). The prediction performance of the updated Cu bioavailability models was similar to or better than that of the models used for regulatory application in Europe until now, with one exception (i.e.,H. azteca). Together with the recently published fish bioavailability model, the models developed in the present study constitute a complete, updated, and consistent bioavailability model set. Overall, the updated chronic Cu bioavailability model set is robust and can be used in regulatory applications. The updated bioavailability model set is currently used under the European Union Registration, Evaluation, Authorisation, and Restriction of Chemicals framework regulation to guide the safe use of Cu.Environ Toxicol Chem2024;43:450–467. © 2023 The Authors.Environmental Toxicology and Chemistrypublished by Wiley Periodicals LLC on behalf of SETAC.