Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma
Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma
复制标题
DOI：
10.3892/or_00000275
复制
发表时间：
2009-03-01
期刊：
影响因子：
4.2
通讯作者：
Hamakawa, Hiroyuki
中科院分区：
文献类型：
--
作者：
Ishikawa, Tohru;Nakashiro, Koh-ichi;Hamakawa, Hiroyuki
Please try later.
Hypoxia promotes the invasive and metastatic potential of tumour cells. A recent study has shown that the activation of the chemokine receptor CXCR4 by lack of oxygen in breast cancer is HIF-1-dependent. We have previously demonstrated that CXCR4 signalling is involved in the establishment of lymph node metastasis in oral squamous cell carcinoma (OSCC). In this study, we investigated a correlation between CXCR4 and HIF-1 alpha expression in OSCC. Immunohistochemistry showed that CXCR4 was expressed in 20 of 85 OSCC tissues, while HIF-1 alpha was expressed in 51 of 85 samples. There was a significant correlation between the expression of CXCR4 and HIF-1 alpha. In human OSCC cells, hypoxia markedly enhanced the expression of both HIF-1 alpha and CXCR4. Furthermore. synthetic small interfering RNA specific for HIF-1 alpha significantly suppressed the expression of this protein, and also attenuated the induction of CXCR4 expression under hypoxic conditions. These results indicated that HIF-1 alpha regulated hypoxia-induced CXCR4 expression in OSCC.