Enzyme-Catalyzed Reactions of the Carcinogen N-Hydroxy-2-fluorenylacetamide with Nucleic Acid
Enzyme-Catalyzed Reactions of the Carcinogen N-Hydroxy-2-fluorenylacetamide with Nucleic Acid
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致癌物 N-羟基-2-芴基乙酰胺与核酸的酶催化反应
作者：
C. King;B. Phillips
通过凝胶过滤105,000g大鼠肝脏上清液获得的蛋白质级分催化肝癌物质N-羟基-2-芴基乙酰胺与核酸的三个反应。辅因子要求和同位素研究表明，所涉及的反应中间体可能是N-2-芴基羟胺，以及N-羟基-2-芴基乙酰胺的磷酸酯和硫酸酯。
A protein fraction obtained by gel filtration of a 105,000g supernatant of rat liver catalyzes three reactions of the hepatocarcinogen N-hydroxy-2-fluorenylacetamide with nucleic acid. Cofactor requirements and isotopic studies suggest that the reactive intermediates involved may be N-2-fluorenylhydroxylamine, and phosphate and sulfate esters of N-hydroxy-2-fluorenylacetamide.