Radiosensitivity nomogram based on circulating neutrophils in thoracic cancer
Radiosensitivity nomogram based on circulating neutrophils in thoracic cancer
复制标题
基于胸癌循环中性粒细胞的放射敏感性列线图
DOI：
10.2217/fon-2018-0398
复制
发表时间：
2019-03-01
期刊：
影响因子：
3.3
通讯作者：
Zhang, Jiandong
中科院分区：
文献类型：
--
作者：
Hu, Pingping;Liu, Qiqi;Zhang, Jiandong
目的：评价中性粒细胞对胸癌患者放射敏感性的预测能力，建立胸癌患者放射敏感性诺模图。方法：我们回顾了398例接受外照射或同步放化疗作为一线治疗的肺癌和食道癌患者。结果：Logistic回归模型显示，中性粒细胞计数和/或转化生长因子-1水平低的患者具有较好的辐射敏感性。此外，还创建了用于预测放射治疗敏感性的诺模图。中性粒细胞计数和转化生长因子-1水平是肺癌和食道癌患者的独立预后因素。结论：本研究建立了基于循环中性粒细胞和转化生长因子-1水平的正常图。中性粒细胞对放射敏感性和促肿瘤效应的预测价值可能与肿瘤相关的中性粒细胞有关。
Aim: To evaluate the prediction ability of neutrophils and develop a nomogram on radiosensitivity in thoracic cancer patients. Methods: We retrospectively reviewed 398 lung and esophageal cancers patients who received external-beam radiotherapy or concurrent chemoradiotherapy as first-line therapy. Results: Logistic regression model showed that patients with low levels of neutrophil counts and/or TGF-1 exhibited better radiation sensitivity. Furthermore, a nomogram was created to predict radiotherapy sensitivity. The combination of neutrophil count and TGF-1 level was an independent prognostic factor for lung and esophageal cancers patients. Conclusion: The study developed a nomogram based on the levels of circulating neutrophils and TGF-1. The prediction value in radiosensitivity and protumorigenic effect of neutrophils might owe to N2 tumor-associated neutrophils.