Growth hormone deficiency and replacement in children
Growth hormone deficiency and replacement in children
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DOI：
10.1007/s11154-020-09604-2
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发表时间：
2020-10-08
影响因子：
8.2
通讯作者：
Boguszewski, Margaret C. S.
中科院分区：
文献类型：
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作者：
Boguszewski, Margaret C. S.
生长激素缺乏(GHD)是一种罕见但可治疗的矮小原因。诊断需要仔细评估临床病史、体格检查和对纵向生长的适当解释，并为每一生命阶段提供特定特征。除生长障碍外，可能还存在其他临床表现，并可能与病因和相关激素缺乏有关。尽管自首次报道生长激素(GH)分泌刺激性试验用于诊断GHD以来，已有50多年的时间，但对结果的解释仍存在争议。当生长激素缺乏症确诊后，建议进行生长激素治疗。治疗是有效和安全的，但在许多年里需要每天注射，这可能会影响依从性。在纵向生长的末期，在过渡期，可能有必要重新评估生长激素的分泌。这篇综述总结和更新了有关儿童生长激素缺乏症的最新信息，以及治疗建议。
Growth hormone deficiency (GHD) is a rare but treatable cause of short stature. The diagnosis requires a careful evaluation of clinical history, physical examination and appropriate interpretation of longitudinal growth, with specific features for each period of life. Other clinical findings, in addition to growth failure, may be present and can be related to the etiology and to associated hormone deficiencies. Despite more than 50 years since the first reports of provocative tests of growth hormone (GH) secretion for the diagnosis of GHD, the interpretation of the results remains a matter of debate. When GHD is confirmed, GH treatment is recommended. Treatment is effective and safe, but requires daily injections during many years, which can affect adherence. At the end of longitudinal growth, during the transition phase, it might be necessary to re-evaluate GH secretion. This review summarizes and updates the recent information related to GHD in children, as well the recommendations for treatment.