Stereoselective Growth of Small Molecule Patches on Nanoparticles.
Stereoselective Growth of Small Molecule Patches on Nanoparticles.
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DOI：
10.1021/jacs.1c04272
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发表时间：
2021-07
影响因子：
15
通讯作者：
Jiajing Zhou;Matthew N Creyer;Amanda A Chen;Wonjun Yim;René P. M. Lafleur;Tengyu He;Zhixing Lin
中科院分区：
文献类型：
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作者：
Jiajing Zhou;Matthew N Creyer;Amanda A Chen;Wonjun Yim;René P. M. Lafleur;Tengyu He;Zhixing Lin
具有空间和化学特异性的可调表面域的片状纳米颗粒具有基本的兴趣，特别是用于创建三维（3D）胶体结构。聚合物的引导组装和区域选择性共轭已被广泛用于操纵纳米颗粒上的这种形貌；然而，这一过程需要预先合成专门的聚合物链和复杂的组装条件。在这里，我们展示了小分子如何在水环境中一步形成3D斑块。贴片的特征（如大小、数量、构象和立体选择性）由可自聚合的芳香二硫醇和复合配体调节，这表明了一种涉及共价聚合和超分子组装的自主组装机制。此外，该方法不依赖于底层纳米颗粒的材料和尺寸，为在纳米尺度上设计非均质贴片提供了一个精简而强大的工具集。
Patchy nanoparticles featuring tunable surface domains with spatial and chemical specificity are of fundamental interest, especially for creating three-dimensional (3D) colloidal structures. Guided assembly and regioselective conjugation of polymers have been widely used to manipulate such topography on nanoparticles; however, the processes require presynthesized specialized polymer chains and elaborate assembly conditions. Here, we show how small molecules can form 3D patches in aqueous environments in a single step. The patch features (e.g., size, number, conformation, and stereoselectivity) are modulated by a self-polymerizable aromatic dithiol and comixed ligands, which indicates an autonomous assembly mechanism involving covalent polymerization and supramolecular assembly. Moreover, this method is independent of the underlying nanoparticle material and dimension, offering a streamlined and powerful toolset to design heterogeneous patches on the nanoscale.