An ionizable lipid toolbox for RNA delivery.

An ionizable lipid toolbox for RNA delivery.
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DOI:
10.1038/s41467-021-27493-0
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发表时间:
2021-12-13
影响因子:
16.6
通讯作者:
Mitchell MJ
Mitchell MJ
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Han X;Zhang H;Butowska K;Swingle KL;Alameh MG;Weissman D;Mitchell MJ

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近年来,RNA疗法取得了令人难以置信的发展,这主要得益于数十年来对脂质纳米颗粒的研究,特别是其关键成分——可电离脂质。本文讨论了可电离脂质的主要类型,并对其未来的发展进行了展望。RNA疗法从几十年来对脂质纳米颗粒的研究中获益良多,特别是其关键成分——可电离脂质。本文讨论了可电离脂质的主要类型,并对其未来的发展进行了展望。
Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development. RNA therapeutics have benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.
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