Paraoxonase 1 Polymorphisms and Risk of Myocardial Infarction in Women and Men
Paraoxonase 1 Polymorphisms and Risk of Myocardial Infarction in Women and Men
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DOI：
10.1253/circj.cj-08-0912
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发表时间：
2009-07-01
影响因子：
3.3
通讯作者：
Rimm, Eric B.
中科院分区：
文献类型：
--
作者：
Mukamal, Kenneth J.;Pai, Jennifer K.;Rimm, Eric B.
背景：以往关于对氧磷酶1(PONI)基因变异与冠心病(CHD)的研究一直是相互矛盾的，影响PONI活性的生活方式因素的改变作用尚不确定。方法和结果：在平行嵌套病例对照研究中，对PONI基因Q192R和L55M多态与冠心病发病的相关性进行了前瞻性研究。女性被追踪8年，男性被追踪6年，249名女性和266名男性被记录为CHID事件。单不饱和脂肪摄入量和吸烟与性别间均无关联，单不饱和脂肪摄入量和吸烟与性别间无交互作用。在女性中，可能存在Q192R与饮酒的交互作用(P交互作用0.06)，并提示与L55M基因型的交互作用相似(P交互作用0.11)。在两种多态分析中，除Q192Q/L55M基因型者外，饮酒量为2.5g/d的女性患冠心病的风险较低(优势比为0.45)。结论：PONI基因多态与冠心病发病风险无关，也与吸烟或单不饱和脂肪摄入量无关。在未来对PONI和CHID的研究中，应考虑可能的基因-酒精相互作用。(保监会J 2009；73：1302-1307)
Background: Previous studies of genetic variants of paraoxonase 1 (PONI) and coronary heart disease (CHD) have been conflicting and the modifying effects of lifestyle factors that affect PONI activity are uncertain.Methods and Results: In parallel nested case-control studies, the prospective associations between PONI polymorphisms Q192R and L55M and incident CHD were examined among participants in the Nurses' Health and Health Professionals Follow-up Studies. Women were followed for 8 years and men for 6 years, and 249 women and 266 men were documented with incident CHID. Neither polymorphism was associated with risk of CHD in either sex, and neither monounsaturated fat intake nor smoking interacted with genotype. Among women, there was a possible interaction of Q192R with alcohol intake (P interaction 0.06) and a suggestion of a similar interaction with the L55M genotype (P interaction 0.11). In analyses of both polymorphisms, alcohol intake >= 2.5 g/day was associated with lower risk among all women (odds ratio 0.45), except those with the Q192Q/L55M genotype (OR 1.33; P 3-way interaction 0.07).Conclusions: PONI polymorphisms are not associated with the risk of CHD nor do they interact with smoking or monounsaturated fat intake. A possible gene-alcohol interaction should be considered in future studies of PONI and CHID. (Circ J 2009; 73: 1302-1307)