Effect of blast-related mTBI on the working memory system: a resting state fMRI study.
Effect of blast-related mTBI on the working memory system: a resting state fMRI study.
复制标题
爆炸相关 mTBI 对工作记忆系统的影响：静息态功能磁共振成像研究。
DOI：
10.1007/s11682-018-9987-9
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发表时间：
2020
影响因子：
3.2
通讯作者：
Kleinhans,Natalia
中科院分区：
文献类型：
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作者：
Pagulayan,KathleenF;Petrie,EricC;Cook,DavidG;Hendrickson,RebeccaC;Rau,Holly;Reilly,Melissa;Mayer,Cindy;Meabon,JamesS;Raskind,MurrayA;Peskind,ElaineR;Kleinhans,Natalia
工作记忆力降低经常被有爆炸相关轻度创伤性脑损伤（mTBI）病史的退伍军人报告，但在神经心理学测量中难以量化。本研究旨在通过使用静息状态功能磁共振成像（fMRI）来探讨有和无mTBI病史的OEF/OIF/OND退伍军人之间功能连接的差异，以提高我们对爆炸相关mTBI对工作记忆系统影响的理解。参与者是24名有爆炸相关mTBI病史的退伍军人和17名部署但没有TBI终身病史的退伍军人。工作记忆能力的评估与听觉辅音三元组（ACT）的任务。静息状态功能磁共振成像被用来评估内在的功能连接，从额叶种子区，是已知的组成部分的工作记忆网络。ACT没有发现显著的组间差异，但成像分析显示，相对于部署的对照组，有mTBI病史的退伍军人的额叶种子区存在广泛的超连接。此外，在mTBI组中，而不是对照组，ACT的更好表现与多个大脑区域的功能连接增加有关，包括工作记忆网络的小脑组件。这些结果是在控制了年龄，PTSD症状和估计的病前智商后出现的，并表明爆炸相关mTBI后工作记忆网络功能连接的长期改变可能反映了一种代偿性变化，有助于工作记忆客观测量的完整表现。
Reduced working memory is frequently reported by Veterans with a history of blast-related mild traumatic brain injury (mTBI), but can be difficult to quantify on neuropsychological measures. This study aimed to improve our understanding of the impact of blast-related mTBI on the working memory system by using resting state functional magnetic resonance imaging (fMRI) to explore differences in functional connectivity between OEF/OIF/OND Veterans with and without a history of mTBI. Participants were twenty-four Veterans with a history of blast-related mTBI and 17 Veterans who were deployed but had no lifetime history of TBI. Working memory ability was evaluated with the Auditory Consonants Trigrams (ACT) task. Resting state fMRI was used to evaluate intrinsic functional connectivity from frontal seed regions that are known components of the working memory network. No significant group differences were found on the ACT, but the imaging analyses revealed widespread hyper-connectivity from the frontal seed regions in the Veterans with a history of mTBI relative to the deployed control group. Further, within the mTBI group, but not the control group, better performance on the ACT was associated with increased functional connectivity to multiple brain regions, including cerebellar components of the working memory network. These results were present after controlling for age, PTSD symptoms, and estimated premorbid IQ, and suggest that long-term alterations in the functional connectivity of the working memory network following blast-related mTBI may reflect a compensatory change that contributes to intact performance on an objective measure of working memory.