Protein S-nitrosylation in health and disease: a current perspective.
Protein S-nitrosylation in health and disease: a current perspective.
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DOI：
10.1016/j.molmed.2009.06.007
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发表时间：
2009-09
影响因子：
13.6
通讯作者：
Stamler JS
中科院分区：
文献类型：
--
作者：
Foster MW;Hess DT;Stamler JS
蛋白质S -亚硝基化在很大程度上体现了一氧化氮对细胞信号转导的普遍影响，越来越多的证据表明S -亚硝基化在正常生理以及多种人类疾病中都起着重要作用。在此，我们回顾了近期的一些研究结果，这些结果表明S -亚硝基化与心血管、肺、肌肉骨骼和神经（功能障碍）以及癌症有关。新出现的情况表明，在很多情况下，病理生理学与特定蛋白质靶点的低S -亚硝基化或高S -亚硝基化相关，而不是由于一氧化氮合酶活性丧失或增强而导致的一般性细胞损伤。此外，越来越明显的是，S -亚硝基化失调不仅可能源于一氧化氮合酶的表达、区室化和/或活性的改变，还可能反映了去亚硝基化酶的作用，其中包括显著的S -亚硝基谷胱甘肽（GSNO）代谢酶——GSNO还原酶。最后，由于蛋白质S -亚硝基化或去亚硝基化的外源性介质可对疾病的发展或进展产生重大影响，调节S -亚硝基化的潜在治疗药物很可能具有广泛的临床应用价值。
Protein S-nitrosylation conveys a large part of the ubiquitous influence of nitric oxide on cellular signal transduction, and accumulating evidence indicates important roles for S-nitrosylation both in normal physiology and in a broad spectrum of human diseases. Here we review recent findings that implicate S-nitrosylation in cardiovascular, pulmonary, musculoskeletal and neurological (dys)function, as well as in cancer. The emerging picture shows that, in many cases, pathophysiology correlates with hypo- or hyper-S-nitrosylation of specific protein targets, rather than a general cellular insult due to loss of or enhanced nitric oxide synthase activity. In addition, it is increasingly evident that dysregulated S-nitrosylation can result not only from alterations in the expression, compartmentalization and/or activity of nitric oxide synthases but can also reflect a contribution from denitrosylases, including prominently the S-nitrosoglutathione (GSNO)-metabolizing enzyme, GSNO reductase. Finally, because exogenous mediators of protein S-nitrosylation or denitrosylation can substantially affect the development or progression of disease, potential therapeutic agents that modulate S-nitrosylation could well have broad clinical utility.
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影响因子：
7.7
作者：
Carvalho, MA;Ueno, M;Saad, MJA
通讯作者：
Saad, MJA
DOI：
10.1073/pnas.93.17.9142
发表时间：
1996-08-20
影响因子：
11.1
作者：
Chang, WJ;Iannaccone, ST;Stull, JT
通讯作者：
Stull, JT
影响因子：
37.8
作者：
Bendall, JK;Damy, T;Heymes, C
通讯作者：
Heymes, C
DOI：
10.1073/pnas.0709118105
发表时间：
2008-03-18
影响因子：
11.1
作者：
Chang, Kuan-Cheng;Barth, Andreas S.;Marban, Eduardo
通讯作者：
Marban, Eduardo
影响因子：
3.3
作者：
Cantarella, Giuseppina;Lempereur, Laurence;Bernardini, Renato
通讯作者：
Bernardini, Renato