Dietary Advanced Glycation End Products and Risk Factors for Chronic Disease: A Systematic Review of Randomised Controlled Trials.
Dietary Advanced Glycation End Products and Risk Factors for Chronic Disease: A Systematic Review of Randomised Controlled Trials.
复制标题
饮食晚期糖基化最终产物和慢性疾病的危险因素：对随机对照试验的系统评价。
DOI：
10.3390/nu8030125
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发表时间：
2016-03-01
期刊：
影响因子：
5.9
通讯作者：
Coughlan MT
中科院分区：
文献类型：
--
作者：
Clarke RE;Dordevic AL;Tan SM;Ryan L;Coughlan MT
食物中的晚期糖基化终产物（AGEs）在食物的加热和加工过程中形成，在现代西方饮食中广泛存在。最近的系统评价表明，饮食中AGEs的消费可能会促进炎症，氧化应激和胰岛素抵抗。实验证据表明，饮食中的AGEs也可能引起肾损伤，然而，这一结果尚未考虑在以前的系统评价。本综述的目的是在人类随机对照试验（RCT）中研究高AGE饮食对慢性疾病（包括慢性肾病（CKD））生物标志物的影响。在6个数据库（SCOPUS、CINHAL、EMBASE、Medline、Biological abstracts和Web of Science）中检索了随机对照饮食试验，这些试验比较了高AGE摄入量与低AGE摄入量在有和无肥胖、糖尿病或CKD的成人中的作用。共确定了12种饮食AGE干预措施，共有293名参与者。在所有人群中，高AGE饮食增加了循环肿瘤坏死因子-α和AGE。高AGE饮食增加了健康成年人的8-异前列腺素和糖尿病患者的血管细胞粘附分子-1（VCAM-1）。CKD的标志物未被广泛评估。现有证据表明，高AGE饮食可能导致与慢性疾病相关的风险因素，如炎症和氧化应激，然而，由于缺乏高质量的随机试验，需要更多的研究。
Dietary advanced glycation end-products (AGEs) form during heating and processing of food products and are widely prevalent in the modern Western diet. Recent systematic reviews indicate that consumption of dietary AGEs may promote inflammation, oxidative stress and insulin resistance. Experimental evidence indicates that dietary AGEs may also induce renal damage, however, this outcome has not been considered in previous systematic reviews. The purpose of this review was to examine the effect of consumption of a high AGE diet on biomarkers of chronic disease, including chronic kidney disease (CKD), in human randomized controlled trials (RCTs). Six databases (SCOPUS, CINHAL, EMBASE, Medline, Biological abstracts and Web of Science) were searched for randomised controlled dietary trials that compared high AGE intake to low AGE intake in adults with and without obesity, diabetes or CKD. Twelve dietary AGE interventions were identified with a total of 293 participants. A high AGE diet increased circulating tumour necrosis factor-alpha and AGEs in all populations. A high AGE diet increased 8-isoprostanes in healthy adults, and vascular cell adhesion molecule-1 (VCAM-1) in patients with diabetes. Markers of CKD were not widely assessed. The evidence presented indicates that a high AGE diet may contribute to risk factors associated with chronic disease, such as inflammation and oxidative stress, however, due to a lack of high quality randomised trials, more research is required.