The nucleus accumbens and ventral pallidum exhibit greater dopaminergic innervation in humans compared to other primates
The nucleus accumbens and ventral pallidum exhibit greater dopaminergic innervation in humans compared to other primates
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与其他灵长类动物相比，人类的伏隔核和腹侧苍白球表现出更强的多巴胺能神经支配
DOI：
10.1007/s00429-021-02300-0
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发表时间：
2021
影响因子：
3.1
通讯作者：
Raghanti, Mary Ann
中科院分区：
文献类型：
--
作者：
Hirter, Kristen N.;Miller, Elaine N.;Stimpson, Cheryl D.;Phillips, Kimberley A.;Hopkins, William D.;Hof, Patrick R.;Sherwood, Chet C.;Lovejoy, C. Owen;Raghanti, Mary Ann
最近的证据表明，背侧纹状体内多巴胺能信号的增加在人类大脑的进化中发挥了重要作用。这种增加与人类的亲社会性和语言有关，被描述为多巴胺主导的纹状体人格风格。纹状体多巴胺的增加与腹侧纹状体活动的增加有关，并促进外部驱动的行为，包括合作和社会整合。相反，纹状体多巴胺减少与背侧纹状体活动增加有关，有利于内部驱动和目标导向的行为。以前的比较研究集中在背侧纹状体，测量背侧和内侧尾状核和壳核的多巴胺能神经支配。在这里，我们通过检查腹侧纹状体的区域来补充这一知识。我们量化了人类、类人猿、阔鼻海豚和猕猴伏隔核和腹侧苍白球中酪氨酸羟化酶免疫反应性轴突的密度，作为多巴胺能神经支配的衡量标准。我们的数据表明，人类在这两种结构中具有显著更大的多巴胺能神经支配，支持了以下假设：人类基底神经节中亲社会神经化学的选择可能有助于我们独特的社会行为特征的进化。
Recent evidence suggests that increased dopaminergic signaling within the dorsal striatum played a central role in the evolution of the human brain. This increase has been linked to human prosociality and language in what has been described as a dopamine-dominated striatum personality style. Increased striatal dopamine is associated with an increase in ventral striatal activity and promotes externally driven behaviors, including cooperation and social conformity. In contrast, decreased striatal dopamine is associated with increased dorsal striatal activity and favors internally driven and goal-oriented behaviors. Previous comparative studies have focused on the dorsal striatum, measuring dopaminergic innervation in the dorsal and medial caudate nucleus and putamen. Here, we add to this knowledge by examining regions of the ventral striatum. We quantified the density of tyrosine hydroxylase–immunoreactive axons, as a measure of dopaminergic innervation, in the nucleus accumbens and ventral pallidum of humans, great apes, platyrrhine and cercopithecid monkeys. Our data show that humans have a significantly greater dopaminergic innervation in both structures, supporting the hypothesis that selection for a prosocial neurochemistry in the human basal ganglia may have contributed to the evolution of our uniquely social behavior profile.
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