Elevated concentration of adenosine 3':5'-cyclic monophosphate in intestinal mucosa after treatment with cholera toxin.
Elevated concentration of adenosine 3':5'-cyclic monophosphate in intestinal mucosa after treatment with cholera toxin.
复制标题
霍乱毒素治疗后肠粘膜中 3:5-环单磷酸腺苷浓度升高。
DOI：
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发表时间：
1970
影响因子：
11.1
通讯作者：
N. D. Goldberg
中科院分区：
文献类型：
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作者：
D. Schafer;W. Lust;B. Sircar;N. D. Goldberg
霍乱弧菌无细胞滤液中的热不稳定因子可使犬肠道粘膜中3‘：5’-环磷酸腺苷(CAMP)的湿重浓度显著升高。滤液腔内给药后1-1.5小时，大约与滤液中不耐热的肠毒素引起的肠道分泌物开始分泌的时间相同，这种增加变得明显。这些结果与环磷酸腺苷可能是霍乱毒素引起的肠道分泌反应的中介这一假说一致。
A heat-labile factor in cell-free filtrate of a Vibrio cholerae culture induces a marked rise in the wet-weight concentration of adenosine 3':5'-cyclic monophosphate (cyclic AMP) in the intestinal mucosa of the dog. The increase becomes appreciable 1-1.5 hr after intraluminal administration of the filtrate, about the same time as the onset of intestinal secretion in response to a heat-labile enterotoxin in the filtrate. These results are consistent with the hypothesis that cyclic AMP may be an intermediary in the intestinal secretory response to cholera toxin.