Measles and atopy in Guinea-Bissau
Measles and atopy in Guinea-Bissau
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DOI：
10.1016/s0140-6736(96)91617-7
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发表时间：
1996-06-29
期刊：
影响因子：
168.9
通讯作者：
Goudiaby, A
中科院分区：
文献类型：
--
作者：
Shaheen, SO;Aaby, P;Goudiaby, A
背景流行病学研究推测，儿童早期感染可预防过敏性致敏，但缺乏支持这一假设的证据。我们调查麻疹感染是否保护对发展的过敏性反应的儿童几内亚，比绍，西非。方法我们进行了一项历史队列研究，在Bandim，半农村地区的比绍，几内亚，比绍的首都。1994年对395名0-6岁的年轻人进行了随访，这些年轻人于1978-80年首次接受调查。我们的分析仅限于262人仍然生活在Bandim的麻疹史，记录在童年，被认为是可靠的。我们将特应性定义为皮肤点刺试验阳性（大于或等于3 mm的伤痕）对七种过敏原中的一种过敏。在133名麻疹感染者中，有12.8%的人是特应性的，在接种过疫苗且未患麻疹的129人中，（比值比，调整潜在混杂变量0.36 [95% CI 0.17-0.78]，p=0.01）。母乳喂养超过一年的参与者不太可能对室内尘螨进行阳性皮肤测试。在调整母乳喂养和其他变量后，麻疹感染与屋尘螨皮肤点刺试验阳性风险的大幅降低相关（屋尘螨的比值比为0.20 [0.05-0.81]，p=0.02; D farinae 0.20 [0.06-0.71]，p=0.01）。解释麻疹感染可以预防非洲儿童特应性的发展。
Background Epidemiological studies have led to speculation that infections in early childhood may prevent allergic sensitisation but evidence to support this hypothesis is lacking. We investigated whether measles infection protects against the development of atopy in children of Guinea-Bissau, West Africa.Methods We conducted a historical cohort study in Bandim, a semi-rural district of Bissau, the capital of Guinea-Bissau. 395 young adults, first surveyed in 1978-80 aged 0-6 years, were followed up in 1994. Our analyses were restricted to 262 individuals still living in Bandim for whom a measles history, documented in childhood, was judged to be reliable. We defined atopy as skin-prick test positivity (greater than or equal to 3 mm weal) to one OF more of seven allergens.Findings 17 (12.8%) of 133 participants who had had measles infection were atopic compared with 33 (25.6%) of 129 of those who had been vaccinated and not had measles (odds ratio, adjusted for potential confounding variables 0.36 [95% CI 0.17-0.78], p=0.01). Participants who had been breastfed for more than a year were less likely to have a positive skin test to housedust mite. After adjustment for breastfeeding and other variables, measles infection was associated with a large reduction in the risk of shin-prick test positivity to housedust mite (odds ratio for Dermatophagoides pteronyssinus 0.20 [0.05-0.81], p=0.02; D farinae 0.20 [0.06-0.71], p=0.01).Interpretation Measles infection may prevent the development of atopy in African children.