Anti-inflammatory action of apoptotic cells in patients with acute coronary syndromes
Anti-inflammatory action of apoptotic cells in patients with acute coronary syndromes
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DOI：
10.1016/j.atherosclerosis.2008.12.042
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发表时间：
2009-08-01
期刊：
影响因子：
5.3
通讯作者：
Manfredi, Angelo A.
中科院分区：
文献类型：
--
作者：
Ferri, Luca A.;Maugeri, Norma;Manfredi, Angelo A.
目的：动脉粥样硬化斑块含有凋亡细胞和吞噬细胞。已知凋亡细胞具有抗炎作用。对于它们在急性冠脉综合征患者中的作用知之甚少。方法和结果：我们在存在或不存在凋亡细胞的情况下，用脂多糖（LPS，100 ng/ml）或肽聚糖（PGN，20 μg/ml）对急性冠脉综合征患者（n = 20）和健康对照（n = 30）外周血中的单核吞噬细胞进行攻击。 24小时后，急性冠状动脉综合征患者的单核吞噬细胞比对照组产生更多的TNFα和IL-10；此外，它们对凋亡细胞的抗炎作用更敏感。凋亡细胞在 C 反应蛋白水平为 3 mg/l 的 ACS 患者中更有效。结论：患有急性冠状动脉综合征和循环 C 反应蛋白水平较低的患者对凋亡细胞的抗炎作用更敏感：这表明存在增强的抗炎反馈回路，这可能有助于防止斑块不稳定。 (C) 2009 Elsevier Ireland Ltd. 保留所有权利。
Objectives: Atherosclerotic plaques contain both apoptotic cells and phagocytes. Apoptotic cells are known to exert an anti-inflammatory effect. Little is known on their action in patients with acute coronary syndromes.Methods and results: We challenged mononuclear phagocytes from the peripheral blood of patients with acute coronary syndromes (n = 20) and healthy controls (n = 30) with lipopolysaccharide (LPS, 100 ng/ml) or peptidoglycan (PGN, 20 mu g/ml) in the presence or in the absence of apoptotic cells. After 24 h, mononuclear phagocytes from patients with acute coronary syndromes produced more TNF alpha and IL-10 than controls; moreover, they were significantly more susceptible to the anti-inflammatory action of apoptotic cells. Apoptotic cells were more effective in ACS patients with C-reactive protein levels 3 mg/l.Conclusions: Patients with acute coronary syndromes and low circulating C-reactive protein levels are more sensitive to the anti-inflammatory action of apoptotic cells: this suggests the existence of an enhanced anti-inflammatory feedback circuit, which could contribute to protect from plaque instability. (C) 2009 Elsevier Ireland Ltd. All rights reserved.