Development of a multipurpose ion source for LC-MS and GC-API MS
Development of a multipurpose ion source for LC-MS and GC-API MS
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DOI：
10.1007/s00216-008-2255-x
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发表时间：
2008-09-01
影响因子：
4.3
通讯作者：
Schmitz, Oliver J.
中科院分区：
文献类型：
--
作者：
Schiewek, Ralf;Lorenz, Matthias;Schmitz, Oliver J.
在过去的十年中，在大气压下操作的多模式离子源（即，在离子源外壳中可操作一种以上的电离方法）受到了相当大的关注。在一次分析运行中同时操作针对不同化合物类别的不同电离方法具有几个优点，包括提高样品通量，从而显著降低实验室成本。潜在的缺点是增强的离子抑制和电离方法的同时操作的其他不期望的影响。在这方面的贡献，我们提出了一种替代方法的发展和表征的一个广泛适用的，多用途的离子源在大气压下工作。优化的源几何结构允许从LC-API方法（ESI、APCI、APLI）快速转换为GC-API方法（APCI、APLI、DA-APLI），同时沿着所需的色谱设备。此外，真正的多模式操作的源被证明为LC-ESI/APLI和LC-APCI/APLI。
Over the past decade, multimode ion sources operating at atmospheric pressure (i.e., more than one ionization method is operative in the ion source enclosure) have received considerable interest. Simultaneous operation of different ionization methods targeting different compound classes within one analysis run has several advantages, including enhanced sample throughput and thus significant laboratory cost reductions. Potential drawbacks are enhanced ion suppression and other undesirable effects of the simultaneous operation of ionization methods. In this contribution we present an alternative approach-the development and characterization of a widely applicable, multipurpose ion source operating at atmospheric pressure. The optimized source geometry allows rapid changing from LC-API methods (ESI, APCI, APLI) to GC-API methods (APCI, APLI, DA-APLI) along with the appropriate coupling of chromatographic equipment required. In addition, true multimode operation of the source is demonstrated for LC-ESI/APLI and LC-APCI/APLI.