Temporal association of cannabis use with symptoms in individuals at clinical high risk for psychosis
Temporal association of cannabis use with symptoms in individuals at clinical high risk for psychosis
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DOI：
10.1016/j.schres.2008.08.008
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发表时间：
2008-12-01
影响因子：
4.5
通讯作者：
Malaspina, Dolores
中科院分区：
文献类型：
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作者：
Corcoran, Cheryl M.;Kimhy, David;Malaspina, Dolores
背景资料：据报道，大麻的使用会增加精神病的风险，但没有前瞻性研究纵向研究药物使用和症状同时在临床高危cases.Method：我们前瞻性随访了长达2年的32例符合前驱精神病研究标准的病例，以检查物质使用和临床措施之间的关系。有大麻使用基线史的病例（41%）年龄较大，但临床指标没有差异。纵向评估显示，这些情况下有显着更多的知觉障碍和更差的功能，在时代的大麻使用，是无法解释的并发使用其他药物或medication.Conclusions：这些数据表明，大麻的使用可能是一个危险因素，为加剧阈下精神病症状，特别是知觉障碍，在高危病例。(C)2008 Elsevier B.V.保留所有权利。
Background: Cannabis use is reported to increase the risk for psychosis, but no prospective study has longitudinally examined drug use and symptoms concurrently in clinical high risk cases.Method: We prospectively followed for up to 2 years 32 cases who met research criteria for prodromal psychosis to examine the relationship between substance use and clinical measures.Results: Cases with a baseline history of cannabis use (41%) were older, but did not differ in clinical measures. Longitudinal assessments showed these cases had significantly more perceptual disturbances and worse functioning during epochs of increased cannabis use that were unexplained by concurrent use of other drugs or medications.Conclusions: These data demonstrate that cannabis use may be a risk factor for the exacerbation of subthreshold psychotic symptoms, specifically perceptual disturbances, in high risk cases. (C) 2008 Elsevier B.V. All rights reserved.