Counterconditioned fear responses exhibit greater renewal than extinguished fear responses
Counterconditioned fear responses exhibit greater renewal than extinguished fear responses
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DOI：
10.1101/lm.040659.115
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发表时间：
2016-04-01
影响因子：
2
通讯作者：
Westbrook, R. Frederick
中科院分区：
文献类型：
--
作者：
Holmes, Nathan M.;Leung, Hiu T.;Westbrook, R. Frederick
这一系列的实验使用大鼠来比较条件反射和条件反射恐惧反应（冻结）的消退对环境变化的影响。在每一个实验中，一个刺激在情境A中与电击配对，在情境B中通过与蔗糖配对而被消除或抵消，然后在情境B之外测试更新。相反的恐惧反应表现出更大的阿坝更新比熄灭的恐惧反应。使用受试者间设计（实验1）和受试者内设计（实验2）观察到这一结果，在受试者内设计中，除了蔗糖信号外，反条件刺激和熄灭刺激在所有方面都是相等的。反条件的恐惧反应也表现出更大的ABC更新比熄灭的恐惧反应（实验3）。使用受试者内设计观察到这一结果，其中背景C在其关联历史方面与背景B相同，并且当在与休克和蔗糖相关联的化合物中测试反条件和熄灭的CS时（实验4）。这些结果是一致的模型认为，上下文调节的协会形成的反条件反射和灭绝的表达，并允许调节的水平是更大的反条件反射比灭绝，在以前的研究中指出。
This series of experiments used rats to compare counterconditioning and extinction of conditioned fear responses (freezing) with respect to the effects of a context shift. In each experiment, a stimulus was paired with shock in context A, extinguished or counterconditioned through pairings with sucrose in context B, and then tested for renewal outside of context B. Counterconditioned fear responses exhibited greater ABA renewal than extinguished fear responses. This result was observed using a between-subjects design (Experiment 1) and a within-subject design in which counterconditioned and extinguished stimuli were equated in all respects other than their signaling of sucrose (Experiment 2). Counterconditioned fear responses also exhibited greater ABC renewal than extinguished fear responses (Experiment 3). This result was observed using a within-subject design in which context C was identical to context B in terms of its associative history, and when counterconditioned and extinguished CSs were tested in compounds matched for their association with both shock and sucrose (Experiment 4). These results are consistent with models which hold that context regulates expression of associations formed in counterconditioning and extinction, and allow the level of regulation to be greater following counterconditioning than extinction, as noted in previous studies.