EFFECT OF DIPSACUS ASPER ON THE EXPRESSION OF AMYLOID PRECURSOR PROTEIN IN THE DORSAL HIPPOCAMPAL FORMATION IN RAT MODEL OF ALZHEIMER DISEASE
EFFECT OF DIPSACUS ASPER ON THE EXPRESSION OF AMYLOID PRECURSOR PROTEIN IN THE DORSAL HIPPOCAMPAL FORMATION IN RAT MODEL OF ALZHEIMER DISEASE
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续断对阿尔茨海默病大鼠模型背海马结构淀粉样前体蛋白表达的影响
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
Qiang Yi
中科院分区：
文献类型：
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作者：
Qiang Yi
阿尔茨海默病 (AD) 尚无有效治疗方法。本文采用氯化铝预处理建立痴呆模型,将AD大鼠分为对照组、续断组、维生素E(VE)三组,分别给予续断组或VE处理1、3、5个月,采用行为学试验、光镜形态观察以及免疫细胞化学结合图像分析的方法。结果表明:1.三组中续断3个时间段的处理asper或VE处理1、3、5个月。①三组大鼠学习记忆能力差异有统计学意义(P<0<05);②海马区淀粉样前体蛋白样免疫反应性(APPLI)神经元的平均面积和吸光度(ASO)三组间差异有统计学意义(P<0<05)。2.对续断asper或VE处理1、3、5个月组间进行纵向比较。月数:①三组大鼠的学习记忆能力也有显着性差异(P<0 0 05或0.01);②三组大鼠背海马区APP LI神经元的平均面积和ASO在三组之间也有显着性差异(P<0 0 1)。这些结果表明续断和VE均能阻止大鼠海马区APP的过度表达,提高大鼠的学习和记忆能力。
There is not an effective cure for Alzheimer disease (AD). In this paper,the model of dementia was established by pretreatment with aluminium chloride,the AD rats were divided into control,dipsacus asper,vitamin E(VE) three groups and were dealt with dipsacus asper or VE for one,three,five months,behaviour test and light microscope morphological observation as well as immunocytochemical method combinating with image analysis were adopted.The results showed that:1.Among the three groups in three time periods which were dealt with dipsacus asper or VE for one,three,five months.①The learning and memorizing abilities of rat significantly different among three groups( P 0 05);②The average area and absorbance (ASO) of the amyloid precursor protein like immunoreactivity (APP LI) neurons in dosal hippocampal formation were significantly different among three groups( P 0 05).2.To make longitudinal comparison among groups which were dealt with dipsacus asper or VE for one,three,five months:①The learning and memorizing abilities of rat were also significant differences among three groups( P 0 05 or 0.01);②The average area and ASO of the APP LI neurons in dosal hippocampal formation were significant differences among three groups( P 0 01).These findings indicate that both dipsacus asper and VE can prevent the overexpression of the APP in dosal hippocampal formation,and improve the learning and memorizing abilities of rat.