Heritability of borderline personality disorder features is similar across three countries
Heritability of borderline personality disorder features is similar across three countries
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DOI：
10.1017/s0033291707002024
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发表时间：
2008-09-01
影响因子：
6.9
通讯作者：
Boomsma, D. I.
中科院分区：
文献类型：
--
作者：
Distel, M. A.;Trull, T. J.;Boomsma, D. I.
背景我们对边缘型人格障碍特征的大部分认识都是通过对临床样本的研究获得的。虽然这些研究本身很重要，但它们在解决某些重要的流行病学和病因学问题方面的能力有限，例如遗传对边缘性人格障碍特征表现的影响程度。虽然边缘型人格障碍的家族史研究表明有遗传影响，但很少有双胞胎研究，边缘型人格障碍的遗传影响程度仍不清楚。数据来自荷兰（n=3918），比利时（n=904）和澳大利亚（n=674）的双胞胎样本。共有来自3644个家庭的5496对年龄在18岁到86岁之间的双胞胎参加了这项研究，他们通过完成一份关于边缘性人格障碍特征的邮寄自我报告问卷获得了数据。在所有国家，女性得分高于男性，年轻人比老年人更倾向于支持边缘型人格障碍特征。模型拟合结果表明，加性遗传影响解释了42%的男性和女性边缘型人格障碍特征的变化，并且这种遗传性估计在荷兰，比利时和澳大利亚之间是相似的。独特的环境影响解释了剩余的58%的方差。在西方社会中，遗传因素在边缘型人格障碍特征的个体差异中发挥作用。
Background. Most of our knowledge about borderline personality disorder features has been obtained through the Study of clinical samples. Although these studies are important in their own right, they are limited in their ability to address certain important epidemiological and aetiological questions such as the degree to which there is a genetic influence on the manifestation of borderline personality disorder features. Though family history studies of borderline personality disorder indicate genetic influences, there have been very few twin Studies and the degree of genetic influence on borderline personality disorder remains unclear.Method. Data were drawn from twin samples from The Netherlands (n=3918), Belgium (n=904) and Australia (n=674). In total, data were available on 5496 twins between the ages of 18 and 86 years from 3644 families who participated in the study by completion of a mailed self-report questionnaire on borderline personality disorder features.Results. In all countries, females scored higher than males and there was a general tendency for younger adults to endorse more borderline personality disorder features than older adults. Model-fitting results showed that additive genetic influences explain 42%, of the variation in borderline personality disorder features in both men and women and that this heritability estimate is similar across The Netherlands, Belgium and Australia. Unique environmental influences explain the remaining 58% of the variance.Conclusions. Genetic factors play a role in individual differences in borderline personality disorder features in Western society.