Impact of lipid-induced degradation on the mechanical properties of ultra-high molecular weight polyethylene for joint replacements.
Impact of lipid-induced degradation on the mechanical properties of ultra-high molecular weight polyethylene for joint replacements.
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DOI：
10.1016/j.jmbbm.2015.08.025
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发表时间：
2016
影响因子：
3.9
通讯作者：
H. Sakoda;S. Niimi
中科院分区：
文献类型：
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作者：
H. Sakoda;S. Niimi
用于人工关节的超高分子质量聚乙烯(UHMWPE)用于灭菌和/或交联剂的伽马或电子束辐照会在材料中产生自由基，从而导致UHMWPE的长期氧化降解。最近，又提出了UHMWPE在体内的临床应用中通过吸收脂质来降解的另一种机制。然而，与自由基诱导的降解相比，关于脂类诱导的降解的知识相当有限。本研究利用角鲨烯吸附和随后的加速老化来模拟脂质诱导的降解，并评价其对UHMWPE力学性能的影响。模拟的脂诱导降解导致弹性模量增加，伸长率降低，最大降解率出现在表面。这些结果表明，即使自由基被完全消除，UHMWPE在体内长期使用也可能发生降解。因此，需要进一步的研究来阐明脂质诱导的降解对临床结果的影响，例如UHMWPE组件的磨损和疲劳特性。
Gamma or electron beam irradiation of ultra-high molecular weight polyethylene (UHMWPE) used in artificial joints for sterilization and/or crosslinking purposes generates free radicals in the material, which causes long-term oxidative degradation of UHMWPE. Recently, another mechanism for the degradation of UHMWPE by the absorption of lipids during in vivo clinical use was proposed. However, knowledge on lipid-induced degradation is quite limited, compared with that on radical-induced degradation. In this study, lipid-induced degradation was simulated using squalene absorption and subsequent accelerated aging, and its impact on the mechanical properties of UHMWPE was evaluated. The simulated lipid-induced degradation caused an increased elastic modulus and decreased elongation with maximum degradation at the surfaces. These results imply that degradation of UHMWPE may occur during in vivo long-term use, even if free radicals are completely eliminated. Therefore, further investigation is required to clarify the impact of lipid-induced degradation on clinical outcomes, such as the wear and fatigue characteristics of UHMWPE components.