The role of structural bioinformatics resources in the era of integrative structural biology.
The role of structural bioinformatics resources in the era of integrative structural biology.
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DOI：
10.1107/s0907444913001157
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发表时间：
2013-05
期刊：
影响因子：
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通讯作者：
Kleywegt GJ
中科院分区：
文献类型：
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作者：
Gutmanas A;Oldfield TJ;Patwardhan A;Sen S;Velankar S;Kleywegt GJ
原子到细胞尺度的结构数据与遗传、分类和功能信息的整合进行了讨论。PDB和EMDB档案的挑战和一些相关的发展PDBE，以解决这些问题进行了讨论。PDB和EMDB档案的历史和当前状态被简要描述，以及它们所面临的一些挑战。结构生物学档案的作用将从纯粹的历史数据库转变为更广泛的生物医学界不可或缺的资源，这似乎是很自然的。作为这一转变的一部分，将有必要验证生物大分子结构数据，确保档案的最高质量，将来自不同空间尺度的结构数据联合收割机合并成一个统一的资源，并将结构数据与功能、遗传和分类数据以及生物信息资源中现有的其他信息结合起来。一些最近的发展和计划，以解决这些挑战在PDBE。
The integration of structural data on atomistic to cellular scales with genetic, taxonomic and functional information is discussed. The challenges to the PDB and EMDB archives and some pertinent developments at PDBe to address these are discussed. The history and the current state of the PDB and EMDB archives is briefly described, as well as some of the challenges that they face. It seems natural that the role of structural biology archives will change from being a pure repository of historic data into becoming an indispensable resource for the wider biomedical community. As part of this transformation, it will be necessary to validate the biomacromolecular structure data and ensure the highest possible quality for the archive holdings, to combine structural data from different spatial scales into a unified resource and to integrate structural data with functional, genetic and taxonomic data as well as other information available in bioinformatics resources. Some recent developments and plans to address these challenges at PDBe are presented.