Shorter telomere length of T-cells in peripheral blood of patients with lung cancer.
Shorter telomere length of T-cells in peripheral blood of patients with lung cancer.
复制标题
肺癌患者外周血T细胞端粒长度较短
DOI：
10.2147/ott.s98488
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发表时间：
2016
影响因子：
4
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Qian Y;Ding T;Wei L;Cao S;Yang L
端粒缩短存在于包括肺癌在内的许多常见恶性肿瘤的肿瘤组织和外周血淋巴细胞中，但其在T细胞中的变化从未被研究过。因此，本研究的目的是评估T细胞端粒长度及其与肺癌患者临床特征的相关性。共选择了40例肺癌患者，但没有既往癌症史和25名健康人。分离T细胞并使用定量实时聚合酶链反应方法测量其端粒长度。肺癌患者T细胞端粒长度明显短于对照组（P<0.001）。较短的端粒长度与临床分期（P=0.008）和远处转移（P=0.028）显著相关。与对照组相比，肺癌患者的幼稚T细胞端粒长度显著缩短（P=0.012）。T细胞端粒长度缩短发生在幼稚T细胞中，可能与肺癌进展有关。
Telomere shortening occurs in tumor tissues and peripheral blood lymphocytes of many common human malignancies, including lung cancer, but its variation in T-cells has never been investigated. Thus, the aim of this study was to assess telomere length in T-cells and its correlation with the clinical characteristics of patients with lung cancer. A total of 40 patients with lung cancer but without prior cancer history and 25 healthy individuals were selected. T-cells were isolated and their telomere lengths were measured using quantitative real-time polymerase chain reaction methods. Telomere length in T-cells was significantly shorter in patients with lung cancer than in controls (P<0.001). Shorter telomere length was significantly associated with increased clinical stage (P=0.008) and distant metastasis (P=0.028). Naïve T-cells from patients with lung cancer had significantly decreased telomere length when compared with those from controls (P=0.012). The shortened telomere length in T-cells occurred in naïve T-cells and might be related to lung cancer progression.