Response Inhibition Mechanism during Ongoing Rapid Reaction：An MEG Study
Response Inhibition Mechanism during Ongoing Rapid Reaction：An MEG Study
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持续快速反应过程中的反应抑制机制：一项 MEG 研究
DOI：
10.11239/jsmbe.56.74
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发表时间：
2018
影响因子：
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通讯作者：
長峯 隆
中科院分区：
文献类型：
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作者：
玉 珍;矢澤 省吾;村原 貴史;齊藤 秀和;篠崎 淳;白石 秀明;松橋 眞生;松山 清治;長峯 隆
准备好的反应在开始前的中断是执行运动功能的一个重要特性，被称为运动抑制。为了阐明运动抑制的机制，我们利用脑磁图研究了暂停快速重复运动的反应产生机制。11名受试者参与了这项研究，并对音调做出了反应。由1和2 kHz音调组成的古怪序列以850 ms的刺激开始异步（SOA）呈现。将80%的频率随机分配给每个人，频率为1 kHz或2 kHz。研究人员要求受试者在听到频繁的音调时灵活地弯曲右手拇指，而在听到罕见的音调时不要移动右手拇指。利用多个等效电流偶极子（ECDs）进行了源分析，并对得到的源位置和时间过程进行了评估。对频繁音调的平均反应时间为168 ~ 267 ms，对罕见音调的成功停止率为84% ~ 96%。发生器源分析显示，双侧听觉皮层被激活，然后左中央区域周围被激活。关于中枢区域的激活，主要运动区域和前运动区域分别被频繁和罕见的音调优先激活。对于罕见的音调，一些受试者的其他区域的皮层，如前额补脑区和下额叶区，也被激活。对罕见音调停止运动的运动前区活动的平均峰值潜伏期为196 ms，而对频繁音调运动反应的运动前区活动的平均峰值潜伏期为257 ms。运动侧对侧的运动前区在运动开始前的抑制反应中起重要作用。
Interruption of prepared responses just before initiation is an important property of executive motor functions, and is known as motor inhibition. To clarify the mechanism of motor inhibition, we investigated the generators of reaction for suspending rapid repetitive movement using magnetoencephalography. Eleven subjects participated in this study and responded to tones. Oddball sequences composed of tones of 1 and 2 kHz were presented at a stimulus onset asynchrony (SOA) of 850 ms. A frequency of 80% was assigned randomly to each individual for either 1 or 2 kHz. Subjects were asked to make brisk right thumb flexion in response to frequent tones and not to move for rare tones. Source analysis with multiple equivalent current dipoles (ECDs) was conducted, and the resulting source locations and time courses were evaluated. The mean reaction time to frequent tones ranged from 168 to 267 ms, and the rate of successful stop after rare tones ranged from 84 to 96%. Generator source analysis revealed activation of bilateral auditory cortexes followed by activation around the left central area. Regarding central area activation, the primary motor and premotor areas were activated preferentially for frequent and rare tones, respectively. For rare tones, cortexes of other areas, such as the presupplementary and inferior frontal areas, were also activated in some subjects. The mean peak latency of the premotor area activity to stop movement for rare tones was 196 ms, whereas that of the primary motor area for motor response to frequent tones was 257 ms. The premotor area contralateral to the moving side plays an important role in inhibiting responses just before movement initiation.