Postgraduate Symposium Do SCFA have a role in appetite regulation?
Postgraduate Symposium Do SCFA have a role in appetite regulation?
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DOI：
10.1017/s0029665110004039
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发表时间：
2011-02-01
影响因子：
7
通讯作者：
Robertson, M. Denise
中科院分区：
文献类型：
--
作者：
Darzi, Julia;Frost, Gary S.;Robertson, M. Denise
最近发现的scfa激活的g偶联蛋白受体FFA受体2和FFA受体3与厌氧性“回肠制动”肠道激素肽YY共定位于l细胞中，也存在于脂肪细胞中，激活刺激瘦素释放。因此，乙酸酯和丙酸酯等短链脂肪酸有望成为增加食物饱腹感的候选物质。因此，我们假设SCFA可能在食欲调节和能量稳态中起作用。短链脂肪酸可以直接在食物中传递，也可以通过提供可发酵的不可消化的碳水化合物间接通过结肠传递。一项调查口服短链脂肪酸对食欲影响的研究综述表明，虽然口服短链脂肪酸与增强饱腹感有关，但这可能是由于产品的适口性而不是短链脂肪酸的生理效应。微菌发酵过程中产生的结肠衍生的短链脂肪酸也被认为可以解释不可消化碳水化合物的饱腹感增强特性。然而，从对益生元胰岛素型果聚糖对食欲的影响的调查中得出的结果是混合的。总的来说，本综述中的数据不支持SCFA在食欲调节中的作用。
The recently discovered SCFA-activated G-coupled protein receptors FFA receptor 2 and FFA receptor 3 are co-localised in L-cells with the anorexigenic 'ileal brake' gut hormone peptide YY, and also in adipocytes, with activation stimulating leptin release. Thus, SCFA such as acetate and propionate show promise as a candidate to increase satiety-enhancing properties of food. We therefore postulate SCFA may have a role in appetite regulation and energy homeostasis. SCFA can be delivered either directly within food, or indirectly via the colon by the provision of fermentable non-digestible carbohydrates. A review of studies investigating the effects of oral SCFA ingestion on appetite suggests that while oral SCFA ingestion is associated with enhanced satiety, this may be explained by product palatability rather than a physiological effect of SCFA. Colon-derived SCFA generated during microfloral fermentation have also been suggested to explain satiety-enhancing properties of non-digestible carbohydrates. However, findings are mixed from investigations into the effects of the prebiotic inulin-type fructans on appetite. Overall, data presented in this review do not support a role for SCFA in appetite regulation.