Facilitation of displacements at the 6-position of purines by the use of 1,4-diazabicyclo[2.2.2]octane as leaving group
Facilitation of displacements at the 6-position of purines by the use of 1,4-diazabicyclo[2.2.2]octane as leaving group
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DOI：
10.1039/a608207f
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发表时间：
1997-02-07
期刊：
影响因子：
--
通讯作者：
Golding, BT
中科院分区：
文献类型：
--
作者：
Lembicz, NK;Grant, S;Golding, BT
6-氯嘌呤与1,4-二氮杂双环[2,2,2]辛烷(DABCO)反应得到相应的“DABCO-嘌呤”1a-d，其在二甲亚砜中与醇盐发生容易的置换反应，得到6-氧基取代的嘌呤。
Reactions of 6-chloropurines with 1,4-diazabicyclo[2,2,2]octane (DABCO) give the corresponding 'DABCO-purines' 1a-d, which undergo facile displacement reactions with alkoxides in dimethyl sulfoxide to afford 6-oxy-substituted purines.