Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults.
Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults.
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DOI：
10.1186/s40795-017-0197-4
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发表时间：
2017-01-01
期刊：
影响因子：
2
通讯作者：
Stephensen, Charles B
中科院分区：
文献类型：
--
作者：
Baldiviez, Lacey M;Keim, Nancy L;Stephensen, Charles B
背景：代谢失衡是慢性病风险的关键决定因素。代谢健康不能仅仅通过体重计算或静态、空腹状态的生化读数来评估。尽管以前的研究描述了对饮食挑战的时间反应，但这些研究未能评估与某些代谢表型相关的环境因素，因此，几乎没有为潜在有效的干预策略提供科学依据。方法/设计：在这项针对健康美国成年人的表型研究中，我们评估了生活方式、生物和环境因素以及代谢参数，以确定与代谢健康变化相关的因素。介绍了一系列实用的健身、饮食和情绪挑战，并监测了不同专业领域的时间反应，包括免疫学、代谢组学和内分泌学。我们期望这项研究将确定与健康或不健康的代谢表型(代谢型)相关的关键因素，这些因素可能成为个人慢性病预防的可修改目标。讨论：这项研究将为以性别、年龄和体重指数定义的平衡阶层的健康成年人的代谢变异性提供新的见解。通常的饮食摄入量和体力活动将在这些层面上进行评估，以确定饮食与健康状况之间的关系，这些指标包括免疫功能、新陈代谢、身体成分、生理学、对运动和饮食挑战的反应以及神经内分泌评估。一个主要的研究目标是确定饮食和其他个人因素，这些因素将在研究参与者中区分不同水平的“健康”。
BACKGROUND: Metabolic imbalance is a key determinant of risk of chronic diseases. Metabolic health cannot be assessed solely by body mass calculations or by static, fasted state biochemical readouts. Although previous studies have described temporal responses to dietary challenges, these studies fail to assess the environmental factors associated with certain metabolic phenotypes and therefore, provide little scientific rationale for potentially effective intervention strategies.METHODS/DESIGN: In this phenotyping study of healthy US adults, we are evaluating lifestyle, biological and environmental factors in addition to metabolic parameters to determine the factors associated with variations in metabolic health. A series of practical fitness, dietary, and emotional challenges are introduced and temporal responses in various areas of specialization, including immunology, metabolomics, and endocrinology, are monitored. We expect that this study will identify key factors related to healthy or unhealthy metabolic phenotypes (metabotypes) that may be modifiable targets for the prevention of chronic diseases in an individual.DISCUSSION: This study will provide novel insights into metabolic variability among healthy adults in balanced strata defined by sex, age and body mass index. Usual dietary intake and physical activity will be evaluated across these strata to determine how diet is associated with health status defined using many indicators including immune function, metabolism, body composition, physiology, response to exercise andmeal challenges and neuroendocrine assessment. A principal study goal is to identify dietary and other personal factors that will differentiate different levels of "health" among study participants.TRIAL REGISTRATION: ClinicalTrials.gov NCT02367287.