Fear-potentiated startle during extinction is associated with white matter microstructure and functional connectivity
Fear-potentiated startle during extinction is associated with white matter microstructure and functional connectivity
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DOI：
10.1016/j.cortex.2014.11.006
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发表时间：
2015-03-01
期刊：
影响因子：
3.6
通讯作者：
Jovanovic, Tanja
中科院分区：
文献类型：
--
作者：
Fani, Negar;King, Tricia Z.;Jovanovic, Tanja
背景资料：条件性恐惧的消退是一个关联学习过程，涉及海马体、内侧前额叶皮层和杏仁核之间的交流。海马体和前扣带皮层（ACC）之间的连接强度，杏仁核和腹内侧前额叶皮层（vmPFC）之间的连接强度，可能会影响恐惧增强惊吓（FPS）反应在灭绝。特定的白色物质束，扣带和钩束（UP），作为这些区域的主要通讯途径。我们的目的是探讨FPS之间的关联在灭绝和扣带和UF connections.Method：扩散张量成像（DTI）和概率纤维束成像分析被用来检查扣带和UF结构连接在40名女性非洲裔美国人的心理创伤暴露。通过右眼轮匝肌肌电图（EMG）评估恐惧条件反射和消退过程中的FPS反应。其次，对用于纤维束成像的种子感兴趣区域（ROI）进行功能连接分析。灭绝早期扣带微结构与FPS之间的显著负相关（r = -.42，p = .01）和晚期灭绝（r =-0.36，p = 0.03）在考虑了年龄、创伤暴露和精神病理学的影响后进行了观察（创伤后应激障碍症状）;这种模式对于这些区域之间的早期灭绝和功能连接是相似的（p <0.05（校正））。FPS和UF microstructure.Conclusions：这些数据表明，扣带结构的完整性直接与灭绝学习，并出现影响这些地区之间的功能连接之间没有显着的相关性。扣带回微结构的减少可能会干扰消退学习，从而增加病理性焦虑的发展风险。(C)2014爱思唯尔有限公司版权所有。
Background: Extinction of conditioned fear is an associative learning process that involves communication among the hippocampus, medial prefrontal cortex, and amygdala. Strength of connectivity between the hippocampus and the anterior cingulate cortex (ACC), and between the amygdala and ventromedial prefrontal cortex (vmPFC), may influence fear-potentiated startle (FPS) responses during extinction. Specific white matter tracts, the cingulum and uncinate fasciculus (UP), serve as primary routes of communication for these areas. Our objective was to investigate associations between FPS during extinction and cingulum and UF connectivity.Method: Diffusion tensor imaging (DTI) and probabilistic tractography analyses were used to examine cingulum and UF structural connectivity in 40 female African-Americans with psychological trauma exposure. FPS responses during fear conditioning and extinction were assessed via electromyography (EMG) of the right orbicularis oculi muscle. Secondarily, functional connectivity analyses were performed with the seed regions of interest (ROIs) used for tractography.Results: A significant negative association between cingulum microstructure and FPS during early extinction (r = -.42, p = .01) and late extinction (r = -.36, p = .03) was observed after accounting for the effects of age, trauma exposure, and psychopathology (post-traumatic stress disorder symptoms); this pattern was similar for early extinction and functional connectivity between these regions (p < .05(corrected)). No significant correlations were observed between FPS and UF microstructure.Conclusions: These data indicate that structural integrity of the cingulum is directly associated with extinction learning and appears to influence functional connectivity between these regions. Decrements in cingulum microstructure may interfere with extinction learning, thereby increasing risk for the development of pathological anxiety. (C) 2014 Elsevier Ltd. All rights reserved.