Methysergide delays the decompensatory responses to severe hemorrhage by activating 5-HT(1A) receptors.
Methysergide delays the decompensatory responses to severe hemorrhage by activating 5-HT(1A) receptors.
复制标题
Methysergide 通过激活 5-HT(1A) 受体来延迟对严重出血的失代偿反应。
DOI：
10.1152/ajpregu.2000.279.5.r1776
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Brooks,VL
中科院分区：
文献类型：
--
作者：
Scrogin,KE;Johnson,AK;Brooks,VL
Central administration of the serotonin receptor ligand methysergide delays the decompensatory response to hypotensive hemorrhage. This study was performed to determine the receptor subtype that mediates this effect. Lateral ventricular (LV) injection of methysergide (40 μg) delayed the hypotensive, bradycardic, and sympathoinhibitory responses to blood withdrawal (1.26 ml/min) in conscious rats. The response was quantified, in part, as the blood volume withdrawal that produced a 40-mmHg fall in blood pressure. The delayed hypotensive response produced by methysergide (8.2 ± 0.2 vs. 5.6 ± 0.2 ml,P< 0.01) was reversed by the 5-hydroxytryptamine (HT)1Aantagonist WAY-100635 (30 μg iv: 6.7 ± 0.4 ml,P< 0.01; 100 μg iv: 5.6 ± 0.1 ml,P< 0.01). LV injection of the 5-HT1Aagonist (+)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) also delayed the hypotensive (10 μg: 8.6 ± 0.3,P< 0.01; 20 μg: 9.2 ± 0.3 ml,P< 0.01), bradycardic, and sympathoinhibitory responses to hemorrhage. WAY-100635 (10 μg iv) completely reversed the effects of 8-OH-DPAT (20 μg: 5.4 ± 0.3 ml). Neither selective blockade of 5-HT2receptors nor stimulation of 5-HT1B/1Dreceptors had any effect on hemorrhage responses. These data indicate that methysergide stimulates 5-HT1Areceptors to delay the decompensatory responses to hemorrhage.
