Relaxation of stretched DNA in slitlike confinement
Relaxation of stretched DNA in slitlike confinement
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DOI：
10.1103/physrevlett.99.238102
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发表时间：
2007-12-07
影响因子：
8.6
通讯作者：
Doyle, P. S.
中科院分区：
文献类型：
--
作者：
Balducci, A.;Hsieh, C. -C.;Doyle, P. S.
我们通过实验观察了两个独立的时间尺度，它们控制着狭缝限制中单个双链 DNA 的线性力延伸机制中的熵反冲。我们证明了松弛过程中不同扩展处存在两种不同的松弛机制。与批量测量相反，真正的最长弛豫时间只能在非常接近平衡的情况下进行探测。松弛机制的简单模型可以进行标度分析，正确预测两种状态之间交叉处的延伸。
We experimentally observe two separate time scales governing the entropic recoil in the linear force-extension regime of single double-stranded DNA in slit confinement. We demonstrate the existence of two distinct relaxation regimes at different extensions during relaxation. Contrary to bulk measurements, the true longest relaxation time may only be probed very close to equilibrium. A simple model of the relaxation mechanism leads to a scaling analysis that correctly predicts the extension at the crossover between the two regimes.