SIRODESMINS A, B, C, AND G, ANTIVIRAL EPIPOLYTHIOPIPERAZINE-2,5-DIONES OF FUNGAL ORIGIN - X-RAY ANALYSIS OF SIRODESMIN-A DIACETATE
SIRODESMINS A, B, C, AND G, ANTIVIRAL EPIPOLYTHIOPIPERAZINE-2,5-DIONES OF FUNGAL ORIGIN - X-RAY ANALYSIS OF SIRODESMIN-A DIACETATE
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DOI：
10.1039/p19770000180
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发表时间：
1977-01-01
期刊：
影响因子：
--
通讯作者：
FREER, AA
中科院分区：
文献类型：
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作者：
CURTIS, PJ;GREATBANKS, D;FREER, AA
本文报道了分歧赛络丝菌（Sirodesmium diversum）产生的表聚硫代哌嗪-2，5-二酮抗生素赛络丝素A、B、C和G的分离、结构和绝对构型。西罗结蛋白A，epidithiopiperazinedione，的结构，通过X-射线分析衍生的二乙酸酯确定。通过与sirodesmin A的化学和光谱性质的比较，确定了sirodesmin B、C和G分别为表-四-、-三-和-二-硫代哌嗪二酮的结构。sirodesmin B和C与sirodesmin A的区别仅在于多硫桥的大小; sirodesmin A和G是差向异构体。
The isolation, structures and absolute configurations of sirodesmins A, B, C and G, epipolythiopiperazine-2,5-dione antibiotics produced by Sirodesmium diversum, are reported. The structure of sirodesmin A, an epidithiopiperazinedione, was determined by X-ray analysis of the derived diaceate. The structures of sirodesmins B, C and G epi-tetra-, -tri- and -di-thiopiperazinediones, respectively, were determined by comparison of their chemical and spectroscopic properties with those of sirodesmin A. Sirodesmins B and C differ from sirodesmin A only in the size of the polysulfide bridge; sirodesmins A and G are epimers.