Epidemiology of Malassezia-Related Skin Diseases
Epidemiology of Malassezia-Related Skin Diseases
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DOI：
10.1007/978-3-642-03616-3_3
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Cabanes, F. Javier
中科院分区：
文献类型：
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作者：
Sugita, Takashi;Boekhout, Teun;Cabanes, F. Javier
核心信息本章涉及分子生物学方法的范围，包括基于PCR的分析，高通量DNA序列分析，以及在皮肤和环境群落结构和动态研究中使用实时PCR。它强调了每种分子生物学方法在产生马拉色病流行病学数据中的实用性，基于培养的方法的局限性，以及可能影响马拉色病流行病学研究的可能偏倚。与任何疾病或影响健康的事件一样，马拉色菌相关疾病的频率和模式通过描述性流行病学进行检查。因此，本章包括对患者相关因素（如年龄、免疫状态和性别）和环境因素（如地理区域和一年中的时间）的评估，这些因素有助于分析马拉色菌引起或马拉色菌加重疾病的风险。本文还对马拉色菌在动物中的流行病学以及与动物宿主及其皮肤微环境有关的因素作了较全面的介绍。
Core MessagesThis chapter deals with the range of molecular biology methods including PCR-based assays, high-throughput DNA sequence analysis, and the use of real-time PCR in performing studies of skin and environmental community structure and dynamics. It highlights the utility of each molecular biology method in yieldingMalasseziaepidemiological data, the limitations of culture-based methods, and the possible biases that may influenceMalasseziaepidemiological studies. As in any disease or health-impacting event, the frequency and patterns ofMalassezia-related diseases is examined by descriptive epidemiology. Thus, the chapter includes assessment of patient-related factors such as age, immunological status and gender, and environmental factors such as the geographical area and time of the year that contribute to the analysis of risks fromMalassezia-induced orMalassezia-exacerbated disease. Also, a comprehensive account is given on theMalasseziaepidemiology in animals and the factors associated with the animal hosts and their skin microenvironment.