Behavioral and neural correlates of hide-and-seek in rats
Behavioral and neural correlates of hide-and-seek in rats
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DOI：
10.1126/science.aax4705
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发表时间：
2019-09-13
期刊：
影响因子：
56.9
通讯作者：
Brecht, Michael
中科院分区：
文献类型：
--
作者：
Reinhold, Annika Stefanie;Sanguinetti-Scheck, Juan Ignacio;Brecht, Michael
哺乳动物游戏的进化、认知和神经基础尚未完全阐明。我们和老鼠玩捉迷藏，这是一种精心设计的角色扮演游戏。我们没有提供食物奖励，而是在发现或被发现后进行有趣的互动。老鼠很快学会了这个游戏，并学会了在隐藏和寻找角色之间交替。它们通过视觉和过去隐藏位置的记忆引导寻找，并发出特定于游戏事件的声音。隐藏时，大鼠发声不频繁，他们喜欢不透明的透明隐藏外壳，在寻求没有观察到的偏好。神经元记录显示，强烈的前额叶皮层活动，不同的游戏事件和审判类型（“隐藏”与“寻找”），并可能指导角色扮演。老鼠对捉迷藏的复杂认知能力表明，这种游戏可能在进化上很古老。
Evolutionary, cognitive, and neural underpinnings of mammalian play are not yet fully elucidated. We played hide-and-seek, an elaborate role-play game, with rats. We did not offer food rewards but engaged in playful interactions after finding or being found. Rats quickly learned the game and learned to alternate between hiding versus seeking roles. They guided seeking by vision and memories of past hiding locations and emitted game event-specific vocalizations. When hiding, rats vocalized infrequently and they preferred opaque over transparent hiding enclosures, a preference not observed during seeking. Neuronal recordings revealed intense prefrontal cortex activity that varied with game events and trial types ("hide" versus "seek") and might instruct role play. The elaborate cognitive capacities for hide-and-seek in rats suggest that this game might be evolutionarily old.