Neurotoxicity of Vanadium.
Neurotoxicity of Vanadium.
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DOI：
10.1007/978-3-319-60189-2_14
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发表时间：
2017
影响因子：
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通讯作者：
H. A. Ngwa;Muhammet Ay;Huajun Jin;V. Anantharam;A. Kanthasamy;A. Kanthasamy
中科院分区：
文献类型：
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作者：
H. A. Ngwa;Muhammet Ay;Huajun Jin;V. Anantharam;A. Kanthasamy;A. Kanthasamy
钒（V）是一种过渡金属，以多种氧化态和多种无机化合物存在，也是一种超痕量元素，被认为是大多数生物体所必需的。尽管是最轻的金属之一，但V具有高结构强度和良好的耐腐蚀性，因此已被广泛用于高强度钢制造。高剂量的V暴露是有毒的，吸入V会对呼吸系统产生不利影响。V的神经毒理学特性刚刚开始被确定。我们小组和其他人最近的研究表明，这种金属在黑质纹状体系统和中枢神经系统（CNS）的其他部分的神经毒性潜力。V的神经毒性作用主要归因于其诱导活性氧（ROS）产生的能力。值得注意的是，由职业性V暴露引起的神经毒性通常与其他金属，特别是锰（Mn）的共同暴露发生。本文主要介绍了维生素V的化学、药理、毒理和神经毒性。
Vanadium (V) is a transition metal that presents in multiple oxidation states and numerous inorganic compounds and is also an ultra-trace element considered to be essential for most living organisms. Despite being one of the lightest metals, V offers high structural strength and good corrosion resistance and thus has been widely adopted for high-strength steel manufacturing. High doses of V exposure are toxic, and inhalation exposure to V adversely affects the respiratory system. The neurotoxicological properties of V are just beginning to be identified. Recent studies by our group and others demonstrate the neurotoxic potential of this metal in the nigrostriatal system and other parts of the central nervous system (CNS). The neurotoxic effects of V have been mainly attributed to its ability to induce the generation of reactive oxygen species (ROS). It is noteworthy that the neurotoxicity induced by occupational V exposure commonly occurs with co-exposure to other metals, especially manganese (Mn). This review focuses on the chemistry, pharmacology, toxicology, and neurotoxicity of V.