Unveiling synaptic plasticity: a new graphical and analytical approach
Unveiling synaptic plasticity: a new graphical and analytical approach
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DOI：
10.1016/s0166-2236(99)01520-9
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发表时间：
2000-03-01
影响因子：
15.9
通讯作者：
Silver, RA
中科院分区：
文献类型：
--
作者：
Clements, JD;Silver, RA
短期突触可塑性在中枢神经系统的信息处理中起着关键作用，而记忆可以通过突触强度的长期变化形成。尽管这些现象很重要，但很难确定突触调节是在突触前还是突触后表达。本文描述了一种新的方法，以其最简单的形式，可以通过直接的图形手段识别表达的地点。该技术的一种更复杂的形式可以量化功能性突触特性，并确定哪些特性在突触强度调节后发生改变。
Short-term synaptic plasticity has a key role in information processing in the CNS, whereas memories can be formed through long-lasting changes in synaptic strength. Despite the importance of these phenomena, it remains difficult to determine whether a synaptic modulation is expressed at a presynaptic or postsynaptic site. This article describes a new approach that, in its simplest form, can identify the site of expression by direct graphical means. A more-sophisticated form of the technique can quantify functional synaptic properties and determine which of these properties is altered following a modulation of synaptic strength.