Gait-Phase Modulates Alpha and Beta Oscillations in the Pedunculopontine Nucleus.
Gait-Phase Modulates Alpha and Beta Oscillations in the Pedunculopontine Nucleus.
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步态时相对桥脑顶核的α和β振荡的调节作用
DOI：
10.1523/jneurosci.0770-21.2021
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发表时间：
2021-10-06
期刊：
影响因子：
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通讯作者：
Tan H
中科院分区：
文献类型：
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作者：
He S;Deli A;Fischer P;Wiest C;Huang Y;Martin S;Khawaldeh S;Aziz TZ;Green AL;Brown P;Tan H
桥脚核（PPN）是位于中脑和桥脑桥交界处的网状神经元集合，在调节姿态和运动中起重要作用。脑深部电刺激PPN已被提出作为一种新兴的治疗帕金森病（PD）或多系统萎缩（MSA）患者的步态相关的非典型帕金森综合征。在这项研究中，我们研究了PPN在步态中的活动，以更好地了解其在运动中的功能作用。具体来说，我们研究了运动过程中PPN的活动是否受到步态周期的节律调节。记录PD或MSA患者在原地踏步或自由行走时步态困难的PPN局部场电位（LFP）活动。通过力板或加速度计的同步测量来确定每个时间点每个步态周期内的相位。结果表明，在步态周期内，PPN lfp的α和β频段活动受到步态相位的节律调节，且步进节奏越规律，调制指数越高。同时，ppn -皮质相干性在α波段最为突出。α / β功率的步态相位相关调制和α频段的PPN -皮质相干性在空间上都是特定于PPN的，并且没有扩展到周围区域。这些结果表明交替PPN调制可能支持步态控制。通过交替刺激来增强交替PPN调制是否会对步态控制产生积极影响还有待检验。意义声明：桥脚核（PPN）脑深部电刺激（DBS）的治疗效果及其改善生活质量的程度尚不明确。了解PPN活动是如何通过步行调节的，可能有助于了解如何提高PPN DBS在改善步态困难方面的疗效。我们的研究表明，PPN α和β的活动受到步态阶段的调节，当步伐节奏规律时，这种调节最为明显。通过交替刺激来增强交替PPN调制是否会对步态控制产生积极影响还有待检验。
The pedunculopontine nucleus (PPN) is a reticular collection of neurons at the junction of the midbrain and pons, playing an important role in modulating posture and locomotion. Deep brain stimulation of the PPN has been proposed as an emerging treatment for patients with Parkinson's disease (PD) or multiple system atrophy (MSA) who have gait-related atypical parkinsonian syndromes. In this study, we investigated PPN activities during gait to better understand its functional role in locomotion. Specifically, we investigated whether PPN activity is rhythmically modulated by gait cycles during locomotion. PPN local field potential (LFP) activities were recorded from PD or MSA patients with gait difficulties during stepping in place or free walking. Simultaneous measurements from force plates or accelerometers were used to determine the phase within each gait cycle at each time point. Our results showed that activities in the alpha and beta frequency bands in the PPN LFPs were rhythmically modulated by the gait phase within gait cycles, with a higher modulation index when the stepping rhythm was more regular. Meanwhile, the PPN–cortical coherence was most prominent in the alpha band. Both gait phase-related modulation in the alpha/beta power and the PPN–cortical coherence in the alpha frequency band were spatially specific to the PPN and did not extend to surrounding regions. These results suggest that alternating PPN modulation may support gait control. Whether enhancing alternating PPN modulation by stimulating in an alternating fashion could positively affect gait control remains to be tested. SIGNIFICANCE STATEMENT The therapeutic efficacy of pedunculopontine nucleus (PPN) deep brain stimulation (DBS) and the extent to which it can improve quality of life are still inconclusive. Understanding how PPN activity is modulated by stepping or walking may offer insight into how to improve the efficacy of PPN DBS in ameliorating gait difficulties. Our study shows that PPN alpha and beta activity was modulated by the gait phase, and that this was most pronounced when the stepping rhythm was regular. It remains to be tested whether enhancing alternating PPN modulation by stimulating in an alternating fashion could positively affect gait control.