Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion
Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion
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DOI：
10.1006/scbi.2000.0367
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发表时间：
2001-04-01
影响因子：
14.5
通讯作者：
Collard, JG
中科院分区：
文献类型：
--
作者：
Price, LS;Collard, JG
Rho样GTP酶调节细胞-细胞和细胞-基质黏附，RAN在体外影响肿瘤细胞的运动和侵袭特性。增加的RAC信号可以促进细胞间的黏附或运动，这取决于细胞类型和细胞外基质的组成。最终，Rac和Rho活性和细胞内定位的平衡似乎是决定细胞表型的关键。
Rho-like GTPases regulate both cell-cell and cell-matrix adhesions and ran influence the motile and invasive properties of tumour cells in vitro. Increased Rac signalling can promote either cell-cell adhesion or motility depending on the cell type and composition of the extracellular matrix. Ultimately, the balance of Rac and Rho activities and intracellular localization appears to be critical in determining the cellular phenotype.