Prognostic roles of MAGE family members in breast cancer based on KM-Plotter Data
Prognostic roles of MAGE family members in breast cancer based on KM-Plotter Data
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DOI：
10.3892/ol.2019.10722
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发表时间：
2019-10-01
期刊：
影响因子：
2.9
通讯作者：
Yang, Yuemei
中科院分区：
文献类型：
--
作者：
Jia, Binghan;Zhao, Xiaoling;Yang, Yuemei
乳腺癌是全世界妇女癌症相关死亡的第二大原因，在西方国家，与这种疾病相关的患病率和死亡率都很高。黑素瘤相关抗原（法师）家族蛋白是众所周知的肿瘤特异性抗原;该家族包括在细胞周期退出、神经元分化和凋亡中起重要作用的>60种蛋白。本研究的目的是鉴定法师家族中对乳腺癌特异的生物标志物。在本研究中，法师mRNA表达的预后作用进行了调查，在乳腺癌患者使用Kaplan-Meier Kaplan-Meier数据库。进一步研究了法师成员在乳腺癌不同内在亚型中的预后价值，以及该疾病的临床病理特征。本研究的结果表明，具有MAGEA 5、MAGEA 8、MAGEB 4和MAGEB 6的高mRNA表达水平的乳腺癌患者具有改善的无复发生存期，而具有MAGEB 18和MAGED 4的高mRNA表达水平的乳腺癌患者则没有。这些结果提示MAGEA 5、MAGEA 8、MAGEB 4和MAGEB 6在乳腺癌的发生和发展中可能具有肿瘤抑制作用，而MAGEB 18和MAGED 4可能具有致癌潜力。MAGED 2、MAGED 3和MAGEF 1根据乳腺癌的类型具有不同的作用。特别是，MAGEC 3 mRNA的高表达与淋巴结阳性乳腺癌的RFS较差相关，但与淋巴结阴性乳腺癌的RFS改善相关。在野生型TP 53和不同病理分级的乳腺癌患者中，MAGEE 2、MAGEH 1和MAGEL 2作为潜在的预后因素更值得关注。本研究的结果可能有助于阐明法师家族成员在乳腺癌发展中的作用，并可能促进进一步的研究，确定MAGE靶向试剂用于治疗乳腺癌。
Breast cancer is the second leading cause of cancer-associated mortality among women worldwide, and the prevalence and mortality rates associated with this disease are high in Western countries. The melanoma-associated antigen (MAGE) family proteins are well-known tumor-specific antigens; this family includes >60 proteins that serve an important part in cell cycle withdrawal, neuronal differentiation and apoptosis. The aim of the present study was to identify a biomarker within the MAGE family that is specific for breast cancer. In the present study, the prognostic role of MAGE mRNA expression was investigated in patients with breast cancer using the Kaplan-Meier plotter database. The prognostic value of MAGE members in the different intrinsic subtypes of breast cancer was further investigated, as well as the clinicopathological features of the disease. The results of the present study indicated that patients with breast cancer that had high mRNA expression levels of MAGEA5, MAGEA8, MAGEB4 and MAGEB6 had an improved relapse-free survival, whereas those with high mRNA expression levels of MAGEB18 and MAGED4 did not. These results suggested that MAGEA5, MAGEA8, MAGEB4 and MAGEB6 may have roles as tumor suppressors in the occurrence and development of breast cancer, whereas MAGEB18 and MAGED4 may possess carcinogenic potential. MAGED2, MAGED3 and MAGEF1 had different effects depending on the type of breast cancer. In particular, high MAGEC3 mRNA expression was associated with worse RFS in lymph node-positive breast cancer, but with improved RFS in lymph node-negative breast cancer. In patients with wild-type TP53 and patients with different pathological grades of breast cancer, MAGEE2, MAGEH1 and MAGEL2 were more worthy of attention as potential prognostic factors. The results of the present study may help to elucidate the role of MAGE family members in the development of breast cancer, and may promote further research that identifies MAGE-targeting reagents for the treatment of breast cancer.