Roles of Remote and Contact Forces in Epithelial Cell Structure Formation
Roles of Remote and Contact Forces in Epithelial Cell Structure Formation
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DOI：
10.1016/j.bpj.2020.01.037
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发表时间：
2020-03-24
影响因子：
3.4
通讯作者：
Haraguchi, Tokuko
中科院分区：
文献类型：
--
作者：
Nakano, Tadashi;Okaie, Yutaka;Haraguchi, Tokuko
癌细胞共同形成一个大规模的结构，以供其生长。在这篇文章中，我们报告说，HeLa细胞，上皮样人宫颈癌细胞，积极迁移基质胶，并形成一个大规模的结构，在细胞密度依赖性的方式。为了解释实验结果，我们开发了一个简单的模型，其中细胞使用两种根本不同类型的力（远程力和接触力）相互作用和迁移，并展示了细胞如何形成大规模结构。我们证明，简单的模型再现实验观察，这表明在这项工作中考虑的远程和接触力发挥了重要作用，在大规模的HeLa细胞的结构形成。这篇文章提供了重要的证据，证明癌细胞形成了一个大规模的结构，并发展了对其结构形成机制的理解。
Cancer cells collectively form a large-scale structure for their growth. In this article, we report that HeLa cells, epithelial-like human cervical cancer cells, aggressively migrate on Matrigel and form a large-scale structure in a cell-density-dependent manner. To explain the experimental results, we develop a simple model in which cells interact and migrate using the two fundamentally different types of force, remote and contact forces, and show how cells form a large-scale structure. We demonstrate that the simple model reproduces experimental observations, suggesting that the remote and contact forces considered in this work play a major role in large-scale structure formation of HeLa cells. This article provides important evidence that cancer cells form a large-scale structure and develops an understanding into the poorly understood mechanisms of their structure formation.